systemic therapy


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systemic therapy

Therapeutics Any therapy that reaches target tissues via the systemic circulation
References in periodicals archive ?
Further analyses were conducted in subgroups stratified according to clinical factors, including RTOG-RPA and GPA, to compare the risk of mortality between radiotherapy followed by systemic therapy and radiotherapy alone.
Patients with resectable CRC liver metastases could be treated with upfront resection to be followed by systemic therapy or by pre- and postoperative systemic therapy.
Given that at least seven biologic and small molecular therapies of varying mechanisms are in phase 2 or 3 development, the options for treatment of patients who need systemic therapy are likely to expand in the coming years.
Impact of cytoreductive nephrectomy on timing of systemic therapy in metastatic kidney cancer.
Among the 20 patients with primary tumors [greater than or equal to] 5 cm, eight received definitive local therapy only, whereas 11 also received additional systemic therapy; one patient received systemic therapy only.
* The patient's non-compliance with the prescribed treatment or his/her refusal to adhere to the study's program (for those who did not consent as regards systemic therapy).
Systemic therapy with oral fusidic acid 500 mg twice a day (Fucidin, Leo Pharmaceutical) was reserved only for lesions surrounded by cellulitis, located around the mid-face, or in presence of systemic symptoms or signs.
KD025-213 is an open-label registration trial of KD025 in adults and adolescents with cGVHD who have received at least two prior lines of systemic therapy. Patients were randomized to receive KD025 200 mg QD or 200 mg BID, enrolling 63 patients per arm.
The approval was based on efficacy and safety data from the randomised, placebo-controlled and double-blind phase three Relief study evaluating the product in 207 adult patients with Behcet's Disease with active oral ulcers who were earlier treated with at least one non-biologic medication and were candidates for systemic therapy. According to the company, the results showcased that the product resulted in a 42.7 point decrease from baseline in the pain of oral ulcers as measured by the visual analogue scale at week 12 compared against 18.7 point reduction with placebo.
Most of this increase was seen in patients with more severe disease: Those with mild disease not on systemic therapy had a risk similar to that of healthy controls.
This text contains 12 chapters by surgeons, dermatologists, and oncologists from the US, who detail surgical aspects of skin cancer, and specifically cover the prevention of future skin cancer; clinical detection; treatment of squamous and basal cell carcinoma, cutaneous melanoma, and rare skin malignancies; Mohs micrographic surgery; radiotherapy; the surgical implications of systemic therapy; common reconstructive techniques after facial skin cancer excision; operative lymphadenectomy; dermatopathology; and high-risk cutaneous malignancies.
Merck, known as MSD outside the United States and Canada, today announced findings from the registrational phase 2 KEYNOTE-224 trial investigating the use of KEYTRUDA (pembrolizumab), the companys anti-PD-1 therapy, in patients with advanced hepatocellular carcinoma (HCC), the most common type of liver cancer, who were previously treated with systemic therapy (sorafenib).

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