systemic inflammatory response syndrome

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Related to systemic inflammatory response syndrome: septic shock

systemic inflammatory response syndrome

clinical state consisting of two or more coexisting conditions: fever or hypothermia, tachycardia, tachypnea, and an abnormally high leukocyte count.

systemic inflammatory response syndrome

clinical state consisting of two or more coexisting conditions: fever or hypothermia, tachycardia, tachypnea, and an abnormally high leukocyte count.
Farlex Partner Medical Dictionary © Farlex 2012

systemic inflammatory response syndrome

A term that 'was developed to imply a clinical response arising from a nonspecific insult and includes two or more of the following. See Sepsis, Septic shock, Severe sepsis.
Systemic inflammatory responses
Temperature < 36ºC or > 38ºC
Heart rate > 90 beats/min
Respiratory rate pCO2 < 32 mm Hg or > 20 breaths/min
WBC count < 4 x 109 or > 12 x 109 or , or the presence of > 0.10 immature neutrophils
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

systemic inflammatory response syndrome



Any severe illness characterized by a heart rate > 90 beats per min, respirations exceeding 20 breaths per minute, a PaCO2 of less than 32 mm Hg, and a white blood count greater than 12,000 cells/mL or less than 4000 cells/mL (or the presence of more than 10 percent immature (band) white blood cells. SIRS can begin with any serious illness or injury involving inflammation but is most often associated with systemic infection (sepsis) caused by gram-negative bacteria. See: sepsis; septic shock


Lipopolysaccharide endotoxins released by gram-negative and gram-positive bacteria bind with lymphocytes and endothelial cells, stimulating a cascade of cytokine release, which produces systemic inflammation of blood vessels, tissues, and organs. Shock develops when cytokines cause vasodilation and increased vascular permeability; SIRS is one of the main causes of multiple organ dysfunction syndrome.


Treatment for SIRS is focused on treating the primary cause. Multiple antibiotic therapy is required in sepsis. Supportive measures include the use of intravenous fluids and pressors, to support blood pressure, and intensive monitoring and optimization of oxygenation, ventilation, blood pressure, cardiac rhythms, serum electrolytes, and renal function.

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References in periodicals archive ?
Williams, "The systemic inflammatory response syndrome in acute liver failure," Hepatology, vol.
Oxidative injury plays a significant role in the development of sepsis and systemic inflammatory response syndrome (SIRS).
Procalcitonin (PCT) is widely used as a diagnostic marker of sepsis and systemic inflammatory response syndrome (SIRS) [3] and has been shown to be a more accurate marker in detection of early postoperative infection after cardiac, intestinal and major neural surgeries compared to the standard laboratory parameters (such as CRP and WBC [1, 4-6]).
Discrimination of sepsis and systemic inflammatory response syndrome by determination of circulating plasma concentrations of procalcitonin, protein complement 3a, and interleukin-6.
Clinical laboratory differentiation of infectious versus non-infectious systemic inflammatory response syndrome. Clin Chim Acta 2005; 351:17-29.
Selenium in Intensive Care (SIC): results of a prospective randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock.
It has been well documented that several factors affect the development and progress of systemic inflammatory response syndrome after open surgery, including operation procedure and time, temperature, humidity, air atmosphere, and blood loss [16-18].
Barie, "Relationship of systemic inflammatory response syndrome to organ dysfunction, length of stay, and mortality in critical surgical illness: effect of intensive care unit resuscitation," Archives of Surgery, vol.
Systemic complications assumed the presence of persistent systemic inflammatory response syndrome (SIRS) and/or developing organ failure.
MODS, a serious and often fatal condition, occurs in patients with septic and toxic shock and other systemic inflammatory response syndromes. In MODS, activated neutrophils infiltrate tissues, resulting in the release of proteases, reactive oxygen species, and various cytokines and inflammatory mediators that contribute to tissue injury and failure.

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