synuclein


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synuclein

(sĭ-no͞o′klē-ĭn)
n.
Any of a family of small proteins, designated alpha, beta, and gamma, that are expressed chiefly in neurons.
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References in periodicals archive ?
Normally, cardiolipin in mitochondria pulls synuclein out of toxic protein deposits and refolds it into a non-toxic shape, the researchers added.
New target for Parkinson's therapy identified
Familial parkinsonism with synuclein pathology: clinical and PET studies of A30P mutation carriers.
Absence of SNCA polymorphisms in Pakistani Parkinson's disease patients
Competent BL21 (DE3) Escherichia coli bacteria were transformed with a plasmid containing the ZF synuclein gene, allowed to grow in 3 L Luria broth to 6.
Neurotoxicity of the Parkinson disease-associated pesticide Ziram is synuclein-dependent in zebrafish embryos
BioArctic AB has entered into a strategically important collaboration with AbbVie (NYSE: ABBV), a global biopharmaceutical company, to develop and commercialize BioArctic's portfolio of antibodies directed against alpha- synuclein for the treatment of Parkinson's disease and other potential indications.
BIOARCTIC AND ABBVIE COLLABORATE FOR RESEARCH
The work is the first to link the release of alpha synuclein, a naturally-occurring protein that plays a central role in the development of Parkinson's, with its most common genetic risk factor--GBA-1--shedding new light on its role in the progression of the devastating neurological condition and its symptoms.
Stem cell study shows how Parkinson's spreads from cell to cell
All vaccines in this pool target alpha- Synuclein, a protein that is key to the onset and the progression of both, Parkinson's and multiple system atrophy (MSA).
PARKINSON'S VACCINE EU-TEAM LAUNCHES CLINICAL TRIAL
To assess the potential of EAS in this regard, we investigated its effect on the SH-SY5Y cells overexpressing wild-type [alpha]- synuclein (WT-[alpha]-Syn) or A53T mutant [alpha]-synuclein (A53T-[alpha]-Syn), and the implicated pathway it might mediate.
Neuroprotective effects of extract of Acanthopanax senticosus harms on SH- SY5Y cells overexpressing wild-type or A53T mutant [alpha]-synuclein
By normalizing brain levels of alpha synuclein, beta amyloid and tau, it provides an avenue to treat Alzheimer's and Parkinson's disease early so as to prevent the onset or diminish the severity of cognitive decline.
Posiphen Restores Brain Function, Cognition and Memory in Transgenic Alzheimer Mice
PsychoGenics has obtained a license from the University of California, San Diego School of Medicine to two of their a- synuclein transgenic mouse models, over-expressing human wild type a-synuclein under control of the PDGF-promoter and the murine Thy-1 promoter.
PSYCHOGENICS OBTAINS LICENSE TO .-SYNUCLEIN
Elevated alpha synuclein mRNA levels are associated with craving in patients with alcoholism.
Methylation status and neurodegenerative markers in parkinson disease
Synuclein deposition and non-motor symptoms in Parkinson disease.
Research on the premotor symptoms of Parkinson's disease: clinical and etiological implications
Parkinson's disease (PD), a neurodegenerative disorder, is characterized by the selective degeneration of the nigrostriatal dopaminergic neurons, continuing or permanent deficiency of dopamine, accretion of an abnormal form of alpha synuclein in the adjacent neurons, and dysregulation of ubiquitin proteasomal system, mitochondrial metabolism, permeability and integrity, and cellular apoptosis resulting in rigidity, bradykinesia, resting tremor, and postural instability.
Melatonin as a neuroprotective agent in the rodent models of Parkinson's disease: is it all set to irrefutable clinical translation?

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