synuclein


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synuclein

(sĭ-no͞o′klē-ĭn)
n.
Any of a family of small proteins, designated alpha, beta, and gamma, that are expressed chiefly in neurons.
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M2 EQUITYBITES-July 29, 2019-Alterity Therapeutics successfully completes Phase 1 study of novel small molecule inhibitor of alpha- synuclein aggregation
Alterity Therapeutics successfully completes Phase 1 study of novel small molecule inhibitor of alpha- synuclein aggregation
Global Banking News-July 29, 2019-Alterity Therapeutics successfully completes Phase 1 study of novel small molecule inhibitor of alpha- synuclein aggregation
Alterity Therapeutics successfully completes Phase 1 study of novel small molecule inhibitor of alpha- synuclein aggregation
M2 PHARMA-July 29, 2019-Alterity Therapeutics successfully completes Phase 1 study of novel small molecule inhibitor of alpha- synuclein aggregation
Alterity Therapeutics successfully completes Phase 1 study of novel small molecule inhibitor of alpha- synuclein aggregation
The poisonous chemical, called alpha synuclein, also clumps together in the grey matter of some dementia sufferers.
Parkinson's cure could be near
Normally, cardiolipin in mitochondria pulls synuclein out of toxic protein deposits and refolds it into a non-toxic shape, the researchers added.
New target for Parkinson's therapy identified
This difficulty in comparing in vitro and in vivo findings is actually common with radiotracers of protein aggregates (amyloid, Tau, and synuclein), which usually display multiple binding components with differential affinities, along with a high level of nonsaturable binding [18, 19].
Amyloid-Beta Radiotracer [[sup.18]F]BF-227 Does Not Bind to Cytoplasmic Glial Inclusions of Postmortem Multiple System Atrophy Brain Tissue
Similarly, since [gamma]-synuclein ([gamma]S), the third member of the synuclein family of peptides [32, 33], may be involved in the regulation of [alpha]S evolvability because [gamma]S is associated with neuritic pathology, such as in dystrophic neurites and spheroid structures, in the brains of sporadic cases of PD, DLB, and neurodegeneration with brain iron accumulation type 1 [34, 35].
Motor and Nonmotor Symptoms of Parkinson's Disease: Antagonistic Pleiotropy Phenomena Derived from [alpha]-Synuclein Evolvability?
Vaccination with recombinant [alpha]-synuclein 6 to 10 weeks before intracerebral injection of [alpha]- synuclein reduced protein inclusions in the SN associated with an increase in [CD4.sup.+] T cells and microglial activation [104].
Linking Neuroinflammation and Neurodegeneration in Parkinson's Disease
Familial parkinsonism with synuclein pathology: clinical and PET studies of A30P mutation carriers.
Absence of SNCA polymorphisms in Pakistani Parkinson's disease patients
An x, y plot of PE%, PC% data points revealed that when PC% + 1.38 PE% > 23.7%, [alpha]-synuclein is soluble, whereas when PC% + 1.38 PE% [less than or equal to] 23.7%, [alpha]- synuclein forms foci.
Ethanolamine and Phosphatidylethanolamine: Partners in Health and Disease
Brundin, "Parkinson's disease and alpha synuclein: is Parkinson's disease a prion-like disorder?" Movement Disorders, vol.
The Contribution of [alpha]-Synuclein Spreading to Parkinson's Disease Synaptopathy
Competent BL21 (DE3) Escherichia coli bacteria were transformed with a plasmid containing the ZF synuclein gene, allowed to grow in 3 L Luria broth to 6.4 x [10.sup.8] cells/ mL, induced with 0.5 mM isopropyl [beta]-D-1thiogalactopyranoside, and incubated for 3 additional hours.
Neurotoxicity of the Parkinson disease-associated pesticide Ziram is synuclein-dependent in zebrafish embryos

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