synthetic lethal

synthetic lethal

a lethal chromosome resulting from RECOMBINATION after CROSSING OVER from nonlethal chromosomes.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
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Here are some recent developments, among them Ras-mediated activation of the Raf family kinases, Ras and the plasma membrane: a complicated relationship, genetically engineered mouse models of K-Ras-driven lung and pancreatic tumors: validation of therapeutic targets, synthetic lethal vulnerabilities in KRAS-mutant cancers, and targeting the MAPK pathway in RAS mutant cancers ([umlaut] Ringgold, Inc., Portland, OR)
TEHRAN (FNA)- Medical researchers detail findings that suggest new synthetic lethal interactions could inhibit the growth of tumors in mesenchymal cells, cells that develop into connective tissue such as those found in bones, soft tissues, and the central nervous system.
Actagene's product portfolio comprises the Oncolome database and techniques including synthetic lethal screening, x-ray crystallography and structure-based drug design for development of new chemical entities against genetic targets, enriched in certain cancer populations.
Synthetic lethal screen identification of chemosensitizer loci in cancer cells.
Cancer, biology, and genetics researchers from North America and Europe discuss the MYC protein and its regulation of expression, protein-protein interactions, genomic recognition, and transcriptional functions; MYC's biological activities in normal cellular processes, including its roles in pluripotency, vertebrate and invertebrate development, DNA replication, apoptosis, and metabolism; the activities that make it a major driver in oncogenicity, including its regulatory mutations, induction of genomic instability, cell competition, and metabolic programming; specific examples of its roles in Burkitt lymphoma, medulloblastoma, and neuroblastoma; and approaches to tumors, including synthetic lethal screens and targeted chemotherapy.
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