synthetic lethal

synthetic lethal

a lethal chromosome resulting from RECOMBINATION after CROSSING OVER from nonlethal chromosomes.
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TEHRAN (FNA)- Medical researchers detail findings that suggest new synthetic lethal interactions could inhibit the growth of tumors in mesenchymal cells, cells that develop into connective tissue such as those found in bones, soft tissues, and the central nervous system.
associate professor of Biomedical Sciences at New York Institute of Technology College of Osteopathic Medicine (NYITCOM) and a team of researchers detail findings that suggest new synthetic lethal interactions could inhibit the growth of tumors in mesenchymal cells, cells that develop into connective tissue such as those found in bones, soft tissues, and the central nervous system.
Led by former UCSF postdoctoral fellow Dai Horiuchi, PhD, now assistant professor of pharmacology at Northwestern Universitys Feinberg School of Medicine, the group searched for synthetic lethal partners of MYC using a clever experimental system developed in collaboration with Paul Yaswen, PhD, of Lawrence Berkeley National Laboratory (Berkeley Lab).
Cancer, biology, and genetics researchers from North America and Europe discuss the MYC protein and its regulation of expression, protein-protein interactions, genomic recognition, and transcriptional functions; MYC's biological activities in normal cellular processes, including its roles in pluripotency, vertebrate and invertebrate development, DNA replication, apoptosis, and metabolism; the activities that make it a major driver in oncogenicity, including its regulatory mutations, induction of genomic instability, cell competition, and metabolic programming; specific examples of its roles in Burkitt lymphoma, medulloblastoma, and neuroblastoma; and approaches to tumors, including synthetic lethal screens and targeted chemotherapy.
Actagene's product portfolio comprises the Oncolome database and techniques including synthetic lethal screening, x-ray crystallography and structure-based drug design for development of new chemical entities against genetic targets, enriched in certain cancer populations.
Synthetic lethal screen identification of chemosensitizer loci in cancer cells.
Mutations in the BRCA1 and BRCA2 genes have been demonstrated to be synthetic lethal in tumor models and in patients.
To identify new improved cancer therapeutic approaches, we will pursue a multi-facetted synthetic lethal approach, which takes advantage of the inherent genetic instability of cancer cells.
We here propose to identify and study synthetic lethal interactions with mutations in nucleophosmin 1 (NPM1) in AML.
AstraZeneca head of the Oncology Innovative Medicines Unit Susan Galbraith said, "Partnering Horizon's excellent capabilities in synthetic lethal screens and validation with our strong oncology discovery and development expertise offers real potential to address the need for novel cancer therapeutics, and ultimately to make a difference to patients.
She added, that matching "Horizon s excellent capabilities in synthetic lethal screens and validation with our strong oncology discovery and development expertise offers real potential to address the need for novel cancer therapeutics".
We have previously probed the unique vulnerabilities of RAS mutant cancer cells using synthetic lethal genome-wide screening approaches.