meperidine

(redirected from synthetic heroin)
Also found in: Dictionary, Thesaurus, Encyclopedia.

analgesic

 [an″al-je´zik]
1. relieving pain.
2. pertaining to analgesia.
3. an agent that relieves pain without causing loss of consciousness.
narcotic analgesic opioid analgesic.
nonsteroidal antiinflammatory analgesic (NSAIA) nonsteroidal antiinflammatory drug.
opiate analgesic (opioid analgesic) any of a class of compounds that bind with a number of closely related specific receptors (opioid receptors) in the central nervous system to block the perception of pain or affect the emotional response to pain; such compounds include opium and its derivatives, as well as a number of synthetic compounds, and are used for moderate to severe pain. Chronic administration or abuse may lead to dependence.

meperidine

(mə-pĕr′ĭ-dēn′)
n.
A synthetic opioid, C15H21NO2, used in its hydrochloride form as an analgesic and sedative. Also called pethidine.

meperidine

An IV opioid analgesic with an active metabolite, normeperidine.
 
Route
Parenteral, oral.
 
Pharmacologic effects
Potent blocker of pain messages to the brain.

Contraindications
Co-administration with MAOI antidepressants (may cause dizziness, lightheadedness, nausea); ritonavir.

T1/2
2–5 hours for relief of moderate to severe pain.
 
Therapeutic range
200–800 ng/mL, meperidine; 130–480 ng/mL, normeperidine.
 
Toxic range
> 7 mg/L.
 
Specimen
Random urine, serum.
 
Method
Urine, TLC; serum, GC.

meperidine

Demerol Pain management An IV agonist opioid analgesic, with an active metabolite, normeperidine Route Parenteral, oral Pharmacologic effects Powerful blocker of pain messages to the brain Contraindications Not coadministered with MAOI antidepressants–may cause dizziness, lightheadedness, nausea. See Opioids.

meperidine

See PETHIDINE.
References in periodicals archive ?
Scientists recently observed that a chemical compound found in synthetic heroin and other illegally manufactured opiates causes brain damage and clinical symptoms that closely match Parkinson's disease (SN: 10/5/85, p.
In a recent overdose medics found a male prisoner had a monstrous cocktail of multiple illegal drugs including cannabis, synthetic heroin, cocaine, paracetamol and benzos.
After several weeks of intensive medical sleuthing, it was finally determined that a clandestine chemist just outside the San Francisco Bay Area was making a synthetic heroin in his garage but had made an error in chemistry and produced the compound 1-methyl-4-phenyl-l,2,3,6-tetrahydropyridine, now widely known as MPTP.
Scientists have, for the first time, observed brain damage characteristic of Parkinson's disease in individuals without any symptoms of the disorder, but who have been exposed to a cell-damaging substance--in this case, synthetic heroin. The finding suggests that exposure to similar toxic substances may predispose people to develop Parkinson's disease later in life when additional brain cell loss occurs as a result of aging, according to study director Donald B.
A powerful synthetic heroin called China White killed 18 in Pittsburgh in 1988.