A case of polymyositis with anti-OJ (isoleucyl-transfer RNA synthetase
"You can think of these 20 synthetases
and 20 tRNAs collectively as a molecular computer that evolution has designed to make gene-to-protein translation happen," Carter said.
Clinical, biochemical, and molecular characterization of patients with glutathione synthetase
(21) reported a correlation between anti-EJ antibody incidence and ILD in PM patients, and established that these antibodies reacted with glycyl-tRNA synthetase
. However, anti-PL-7, anti-PL-12, anti-OJ, anti-Zo (anti-phenylalanyl), and anti-KS (anti-asparaginyl) antibodies were reported to have a stronger correlation with ILD than that between anti-Jo-1 antibody and DM/PM patients.
Autoantibody to alanyl-tRNA synthetase
in patients with idiopathic pulmonary fibrosis.
Two glutamine synthetase
genes, HvGS1_1 (gb| X69087.1) which encodes cytoplasmic glutamine synthetase
[10, 28] and HvGS2 (gb| X53580.1) which encodes chloroplastic glutamine synthetase
[14, 28], were included in the study and analyzed in the shoots and roots in the barley cultivars.
Of these, the GARS gene located on chromosome 7p produces an aminoacyl tRNA synthetase
responsible for charging the associated tRNAs and the first protein of its kind implicated in any inherited human disorder.
By Sanger sequencing, compound heterozygous mutations in alanyl-transfer RNA (tRNA) synthetase
2 ( AARS2 ) (OMIM*612035) were detected [Figure 1]g.
Characterization of the syringomycin synthetase
gene cluster: a link between prokaryotic and eukaryotic peptide synthetases
The reason that intralesional TCA alone is less effective than combination therapy with intralesional TCA and 5-FU is that in addition to inhibitory effect on TGF-ss-induced expression of type 1 collagen gene in human fibroblasts, 5-FU has an inhibitory effect on production of thymidylate synthetase
, thus blocking DNA synthesis.
Koblin DD, Watson JE, Deady JE, Stokstad ELR, Eger EIL Nitrous oxide inactivates methionine synthetase
in human liver.
Enzymes such as nitrate reductase (NR) and glutamine synthetase
(GS) are important in nitrogen metabolism, and their activities have significant effects on nitrate accumulation in tobacco.