synthetase


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Related to synthetase: Glutamine synthetase

synthetase

 [sin´thĕ-tās]
ligase; any of a class of enzymes that catalyze the joining together of two molecules coupled with the breakdown of a pyrophosphate bond in ATP or a similar triphosphate.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

syn·the·tase

(sin'thĕ-tās),
An enzyme catalyzing the synthesis of a specific substance. Synthetase is limited, in the Enzyme Commission Report, to use as a trivial name for the ligases (EC class 6), which in turn are those synthesizing enzymes that require the cleavage of a pyrophosphate linkage in ATP or a similar compound. Reversal of lyase (EC class 4) reactions, producing a synthesis, is indicated (in trivial names) by synthase; such reactions do not involve pyrophosphate cleavage. For individual synthetases, see the specific names.
Farlex Partner Medical Dictionary © Farlex 2012

synthetase

(sĭn′thĭ-tās′, -tāz′)
n.
Any of a group of enzymes that catalyze the synthesis of a compound. Also called synthase.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

syn·the·tase

(sin'thĕ-tās)
An enzyme catalyzing the synthesis of a specific substance.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
A case of polymyositis with anti-OJ (isoleucyl-transfer RNA synthetase) antibodies.
"You can think of these 20 synthetases and 20 tRNAs collectively as a molecular computer that evolution has designed to make gene-to-protein translation happen," Carter said.
Clinical, biochemical, and molecular characterization of patients with glutathione synthetase deficiency.
(21) reported a correlation between anti-EJ antibody incidence and ILD in PM patients, and established that these antibodies reacted with glycyl-tRNA synthetase. However, anti-PL-7, anti-PL-12, anti-OJ, anti-Zo (anti-phenylalanyl), and anti-KS (anti-asparaginyl) antibodies were reported to have a stronger correlation with ILD than that between anti-Jo-1 antibody and DM/PM patients.
Autoantibody to alanyl-tRNA synthetase in patients with idiopathic pulmonary fibrosis.
Two glutamine synthetase genes, HvGS1_1 (gb| X69087.1) which encodes cytoplasmic glutamine synthetase [10, 28] and HvGS2 (gb| X53580.1) which encodes chloroplastic glutamine synthetase [14, 28], were included in the study and analyzed in the shoots and roots in the barley cultivars.
Of these, the GARS gene located on chromosome 7p produces an aminoacyl tRNA synthetase responsible for charging the associated tRNAs and the first protein of its kind implicated in any inherited human disorder.
By Sanger sequencing, compound heterozygous mutations in alanyl-transfer RNA (tRNA) synthetase 2 ( AARS2 ) (OMIM*612035) were detected [Figure 1]g.
Characterization of the syringomycin synthetase gene cluster: a link between prokaryotic and eukaryotic peptide synthetases.
The reason that intralesional TCA alone is less effective than combination therapy with intralesional TCA and 5-FU is that in addition to inhibitory effect on TGF-ss-induced expression of type 1 collagen gene in human fibroblasts, 5-FU has an inhibitory effect on production of thymidylate synthetase, thus blocking DNA synthesis.
Koblin DD, Watson JE, Deady JE, Stokstad ELR, Eger EIL Nitrous oxide inactivates methionine synthetase in human liver.
Enzymes such as nitrate reductase (NR) and glutamine synthetase (GS) are important in nitrogen metabolism, and their activities have significant effects on nitrate accumulation in tobacco.