synthetase


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Related to synthetase: Glutamine synthetase

synthetase

 [sin´thĕ-tās]
ligase; any of a class of enzymes that catalyze the joining together of two molecules coupled with the breakdown of a pyrophosphate bond in ATP or a similar triphosphate.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

syn·the·tase

(sin'thĕ-tās),
An enzyme catalyzing the synthesis of a specific substance. Synthetase is limited, in the Enzyme Commission Report, to use as a trivial name for the ligases (EC class 6), which in turn are those synthesizing enzymes that require the cleavage of a pyrophosphate linkage in ATP or a similar compound. Reversal of lyase (EC class 4) reactions, producing a synthesis, is indicated (in trivial names) by synthase; such reactions do not involve pyrophosphate cleavage. For individual synthetases, see the specific names.
Farlex Partner Medical Dictionary © Farlex 2012

synthetase

(sĭn′thĭ-tās′, -tāz′)
n.
Any of a group of enzymes that catalyze the synthesis of a compound. Also called synthase.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

syn·the·tase

(sin'thĕ-tās)
An enzyme catalyzing the synthesis of a specific substance.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
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References in periodicals archive ?
A case of polymyositis with anti-OJ (isoleucyl-transfer RNA synthetase) antibodies.
Novel case of anti-synthetase syndrome
"You can think of these 20 synthetases and 20 tRNAs collectively as a molecular computer that evolution has designed to make gene-to-protein translation happen," Carter said.
How Genes Were First Translated Into Proteins
Clinical, biochemical, and molecular characterization of patients with glutathione synthetase deficiency.
A case of severe glutathione synthetase deficiency with novel GSS mutations
(21) reported a correlation between anti-EJ antibody incidence and ILD in PM patients, and established that these antibodies reacted with glycyl-tRNA synthetase. However, anti-PL-7, anti-PL-12, anti-OJ, anti-Zo (anti-phenylalanyl), and anti-KS (anti-asparaginyl) antibodies were reported to have a stronger correlation with ILD than that between anti-Jo-1 antibody and DM/PM patients.
The Association of Anti-Aminoacyl-Transfer Ribonucleic Acid Synthetase Antibodies in Patients With Rheumatoid Arthritis and Interstitial Lung Disease
Autoantibody to alanyl-tRNA synthetase in patients with idiopathic pulmonary fibrosis.
Pulmonary Pathologic Manifestations of Anti-Alanyl-tRNA Synthetase (Anti-PL-12)-Related Inflammatory Myopathy
Two glutamine synthetase genes, HvGS1_1 (gb| X69087.1) which encodes cytoplasmic glutamine synthetase [10, 28] and HvGS2 (gb| X53580.1) which encodes chloroplastic glutamine synthetase [14, 28], were included in the study and analyzed in the shoots and roots in the barley cultivars.
Expression Analysis of Nitrogen Metabolism-Related Genes Reveals Differences in Adaptation to Low-Nitrogen Stress between Two Different Barley Cultivars at Seedling Stage
Of these, the GARS gene located on chromosome 7p produces an aminoacyl tRNA synthetase responsible for charging the associated tRNAs and the first protein of its kind implicated in any inherited human disorder.
Glycyl tRNA Synthetase (GARS) Gene Variant Causes Distal Hereditary Motor Neuropathy V
By Sanger sequencing, compound heterozygous mutations in alanyl-transfer RNA (tRNA) synthetase 2 ( AARS2 ) (OMIM*612035) were detected [Figure 1]g.
Leukodystrophy without Ovarian Failure Caused by Compound Heterozygous Alanyl-tRNA Synthetase 2 Mutations
Characterization of the syringomycin synthetase gene cluster: a link between prokaryotic and eukaryotic peptide synthetases.
Activation of Syringomycin and Syringopeptin, Two Major Toxins of Pseudomonas syringae pv. syringae by three Cherry Cultivars
The reason that intralesional TCA alone is less effective than combination therapy with intralesional TCA and 5-FU is that in addition to inhibitory effect on TGF-ss-induced expression of type 1 collagen gene in human fibroblasts, 5-FU has an inhibitory effect on production of thymidylate synthetase, thus blocking DNA synthesis.
Comparison of efficacy of intralesional 5-fluorouracil plus triamcinolone acetonide versus intralesional triamcinolone acetonide in the treatment of keloids
Koblin DD, Watson JE, Deady JE, Stokstad ELR, Eger EIL Nitrous oxide inactivates methionine synthetase in human liver.
Nitrous Oxide is an Effective and Safe Anesthetic
Enzymes such as nitrate reductase (NR) and glutamine synthetase (GS) are important in nitrogen metabolism, and their activities have significant effects on nitrate accumulation in tobacco.
Difference between Burley Tobacco and Flue-Cured Tobacco in Nitrate Accumulation and Chemical Regulation of Nitrate and TSNA Contents

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