syntaxin

(sin-taks'in),

A plasma membrane protein essential for synaptic vesicle fusion.

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References in periodicals archive ?

Primary or familial hemophagocytic lymphohistiocytosis (FHLH) is an autosomal recessive disorder of immune dysfunction caused by mutations in Perforin, Munc 13-4, Syntaxin 11 and STBX2 genes (2-5).

Clinical and laboratory data of primary hemophagocytic lymphohistiocytosis: a retrospective review of the Turkish Histiocyte Study Group / Primer hemofagositik lenfohistiositozisli hastalarin klinik ve labarotuvar verileri; Turk Histiosit calisma grubunun retrospektif derlemesi

We have explored the potential interaction between syntaxin 1A and DAT in rat striatal neurons by examining the ability of botulinum toxin C (BoNT/C), which cleaves syntaxin 1A, to affect DAT phosphorylation and transport activity.

Syntaxin 1A regulates dopamine transporter phosphorylation and activity

Then, the lysates were separated by SDS-PAGE and probed with specific antibodies: SNAP-25 (Abcam, ab66066), SNAP-23 (Abcam, ab3340), syntaxin (Santa Cruz, sc-12736), Vamp2 (Abcam, ab6276), Munc-18 (SYSY, 116002), Phospho-Synaptotagmin (R&D Systems, PPS085), [beta]-ACTIN (Abcam, ab6276), TUBULIN (Abcam, ab15246), and Na/K ATPase (Millipore, 05-369).

Brain-Specific SNAP-25 Deletion Leads to Elevated Extracellular Glutamate Level and Schizophrenia-Like Behavior in Mice

Syntaxin will be responsible for the discovery of new therapeutic candidates and Ipsen will apply its skills to pharmacological, preclinical and clinical assessments of the newly discovered compounds.

Syntaxin, Ipsen to develop botulinum-toxin therapeutics

The SNARE domain of syntaxin mediates a membrane fusion process, involving vesicular transport along the exocytic and endocytic pathways.

Identification of functional and in silico positional differentially expressed genes in the livers of high- and low-marbled Hanwoo steers

Speciality pharmaceutical company Ipsen (Euronext:IPN) and Syntaxin, a biotechnology company, announced today a global strategic collaboration to explore the discovery and development of new compounds in the field of botulinum toxins.

Ipsen and Syntaxin enter into collaboration to develop botulinum-toxin therapeutics

The JBD sequence, fully conserved in both isoforms of Syntaxin (residues 148-155), has been mapped on the structure of Syntaxin-1 [48], which we have chosen as a representative structure also for Syntaxin-2, because they share a sequence identity of 64.4% and sequence similarity of 80% (Figure 3(c)).

Evidence of Presynaptic Localization and Function of the c-Jun N-Terminal Kinase

A group of proteins that are directly involved in the exocytosis of SVs is the SNARE (SNAP Soluble NSF Attachment Protein REceptor) complex formed by synaptobrevin, syntaxin, and synaptosomal-associated protein 25 (SNAP25), which mediates SV fusion with the AZ plasma membrane [18].

Emerging Synaptic Molecules as Candidates in the Etiology of Neurological Disorders

Syntaxin 1A protein is located in the presynaptic region and forms the SNARE complex with SNAP-25 and VAMP2; the SNARE complex is critical in neurotransmission (14).

Novel SNARE Complex Polymorphisms Associated with Multiple Sclerosis: Signs of Synaptopathy in Multiple Sclerosis

Then the cleaved light chain passes through the vesicle into the nerve terminal cytoplasm, and cleaves SNAP-25 and syntaxin to prevent the formation of the SNARE protein complex on the membrane, which allows the neurotransmitters to bind and pass into the muscle and contract.

Chronic Migraine: Burden, Comorbidities, and Treatment/Kronik Migren: Hastalik Yuku, Komorbidite ve Tedavi

Syntaxin 6-mediated Golgi translocation plays an important role in nuclear functions of EGFR through microtubule-dependent trafficking.

Porcine growth hormone induces the nuclear localization of porcine growth hormone receptor in vivo

The autosomal dominant form most commonly occurs as result of microdeletions in STX16, the gene encoding syntaxin 16, while the sporadic form has predilection to GNAS microdeletions involving exon NESP55 (6,7).