Giant cell tumor of tendon sheath (benign synovioma
simulating adamantinoma of the tibia.
These individuals included 20 healthy donors and 8 patients with widespread tumors other than MM (chronic lymphocytic leukemia, lymphoma, synovioma
malignum, glioblastoma multiforme, breast cancer, colorectal carcinoma, and bladder carcinoma), who served as negative controls, and 150 patients with histologically confirmed MM.
Other terms used to describe this entity are synovial cell sarcoma and malignant synovioma
. (2,4) Although the term synovioma
implies a benign condition, further investigations have exposed the aggressive nature of this neoplasm and eventually led to its classification as a high-grade tumor by the American Joint Committee on Cancer.