Cadherin-11 is a surface protein expressed on fibroblasts in the skin and lungs, and fibroblast-like synoviocytes
(FLS) in the joints.
Low-molecular-weight fucoidan inhibits the viability and invasiveness and triggers apoptosis in IL-1beta-treated human rheumatoid arthritis fibroblast synoviocytes
and chondrocytes are also affected by glucocorticoids, but the impact of this in RA is not well understood.
Another signaling pathway activated by TNF-[alpha] is the Akt pathway in RA synoviocytes
(Tian et al.
Androgen conversion in osteoarthritis and rheumatoid arthritis synoviocytes
- androstenedione and testosterone inhibit estrogen formation and favor production of more potent 5alpha-reduced androgens.
1) Multiple factors may contribute to RRA, including multiple drug resistance, (2, 3) risk factors affecting prognosis, complications, chronic viral infections and resistance to apoptosis in fibroblast-like synoviocytes
and inflammatory cells.
Reactive oxygen species induce apoptosis of synoviocytes
Most studies have examined the effects of PGE2, which has been demonstrated in vitro to enhance synthesis or degradation of collagen type II and proteoglycan synthesis (12-15,30,32) in chondrocytes and to regulate the production of matrix metalloproteinases in synoviocytes
and other cell types.
Involvement of nuclear factor kappa B in the regulation of cyclooxygenase-2 expression by interleukin-1 in rheumatoid synoviocytes
Anti malarial agent artesunate inhibits TNF-[alpha]-induced production of proinflammatory cytokines via inhibition of NF-[kappa]B and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes
Glycosaminoglycans have been shown in animal models to have an antioxidant effect which could reduce joint erosion, stimulate biosynthesis of cartilaginous tissue or inhibit its degradation, and also serve as potent regulators of synoviocytes
, which control the integrity of joint fluids (Allen et al.
Ginger extract components suppress induction of chemokine expression in human synoviocytes