Pool platelet-rich plasma lysate therapy increases synoviocyte
proliferation and hyaluronic acid production while protecting chondrocytes from synoviocytederived inflammatory mediators.
mTOR Senses Environmental Cues to Shape the Fibroblast-like Synoviocyte
Response to Inflammation.
Moreover, there is considerable variability between biopsies from a single joint, resulting from variations in lining thickness (Smith et al., 2003), sublining composition, and an unequal distribution of synoviocyte
types in the synovial membrane (Shikichi et al., 1999; Iwanaga et al., 2000).
Abbreviations miRNA: MicroRNA UTR: Untranslated region FLS: Fibroblast-like synoviocyte
RA: Rheumatoid arthritis RF: Rheumatoid factor MRI: Magnetic resonance imaging DMARD: Disease-modifying anti-RA drugs TNF: Tumor necrosis factor LPS: Lipopolysaccharide IL: Interleukin AA: Adjuvant arthritis MMP: Metalloproteinase NF-[kappa]B: Nuclear factor-kappa B TAB: TGF-[beta]-activated kinase 1/MAP3K7 binding protein IKK: Inhibitor of nuclear factor kappa B kinase TRAF2: TNF receptor associated factor 2 TNFAIP-3 : Tumor necrosis factor a-induced protein 3 5-azaC: 5-Aza-2'-deoxycytidine SCID mice: Severe combined immunodecifient mice.
Tan, "Modulatory effect of 1,25-dihydroxyvitamin D3 on IL1[beta]-induced RANKL, OPG, TNF[alpha], and IL-6 expression in human rheumatoid synoviocyte
MH7A," Clinical & Developmental Immunology, vol.
Recent evidence suggests that human articular chondrocyte can actively produce ROS which are released during inflammation of the synovial membrane of synoviocyte
. These ROS with oxidative activity play a key role in the chondrocyte catabolic program, being the mediators and effecters of cartilage damage.
Human MH7A synovial cell is an immortalized cell line by stably transfecting rheumatoid fibroblast-like synoviocyte
cells with SV40 T antigen gene.
Stockmarr et al., "A synoviocyte
model for osteoarthritis and rheumatoid arthritis: response to ibuprofen, betamethasone, and ginger extract--a cross-sectional in vitro study," Arthritis, vol.
ROS are released during inflammation of the Synovial membrane of synoviocyte
. These radical oxygen species with oxidative activity play an important role in the Chondrocyte catabolic program: being the mediators and effecters of cartilage damage.
It is involved in induction of the inflammatory cascade as well as processes destructive to joints, including osteoclast activation and synoviocyte
Ferguson et al., "Inflammatory cytokines epigenetically regulate rheumatoid arthritis fibroblast-like synoviocyte
activation by suppressing HDAC5 expression," Annals of the Rheumatic Diseases, vol.
At 4 and 8 weeks of age, in TARV-inoculated birds, the gastrocnemius tendon sheath showed prominent lymphocytic infiltration in the subsynovium along with mild synoviocyte