synovial sarcoma


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syn·o·vi·al sar·co·ma

a rare malignant tumor of synovial origin, most commonly involving the knee joint and composed of spindle cells usually enclosing slits or pseudoglandular spaces that may be lined by radially disposed epitheliallike cells.

synovial sarcoma

a malignant tumor, composed of synovioblasts, that begins as a soft swelling and often metastasizes through the bloodstream to the lung before it is discovered.

synovial sarcoma

A mesenchymal spindle cell tumour which comprises ±10% of all soft-tissue sarcomas. It is most common in young (age 20 to 40) males, and occurs most commonly around the large joints—knee, ankle, foot, 60% in the legs, 23% in upper extremity. However, it can go any place, as cases have been reported in the penis, lung, vulva, abdominal wall, etc.

Prognosis
50% 5-year survival; extensively calcified synovial sarcomas have a higher (84%) 5-year survival; 40% metastasise to lungs, bone-regional nodes.

Good prognostic factors
Children; < 5cm; <10 mitoses/10hpf; no necrosis; complete excision in first attempt.
 
Adverse prognosticators
Older age, larger size (especially, > 35 cm), necrosis, vascular invasion, high Ki-67 index, high-grade nuclei, poorly differentiated areas, known recurrence.

Synovial sarcoma, histologic types
Biphasic
• Distinct epithelial and spindle cell components.
 
DiffDx
Mesothelioma, carcinosarcoma.

Monophasic

DiffDx, Spindle cell type
Malignant peripheral-nerve sheath tumour, schwanoma, solitary fibrous tumour, fasciitis.

DiffDx, Glandular cell type
Any adenocarcinoma.

Poorly differentiated

DiffDx
Ewing sarcoma and other small round cell tumours.

synovial sarcoma

Surgery A mesenchymal malignancy that comprises ±10% of all soft tissue tumors; it is most common in young–age 20-40 ♂, knee, ankle, foot, etc Prognosis 50% 5-yr survival; extensively calcified SSs have a higher–84% 5-yr survival. See Sarcoma, Soft tissue tumors.
References in periodicals archive ?
Shokat was diagnosed with a rare form of cancer called monophasic synovial sarcoma three years ago.
The Huffington Post reported, "The seniors of Profile Junior-Senior High School in Bethlehem, New Hampshire, donated nearly $8,000 to Courtney Vashaw, who is battling synovial sarcoma, a rare soft-tissue cancer.
Her premier novel highlights a young boy's passion for baseball and his determination to honor his father who lost his battle with Synovial Sarcoma.
Cystic renal cell carcinoma (RCC), multilocular cystic RCC, and primary renal synovial sarcoma constitute malignant cystic neoplasms.
1,2,4,5) Parapharyngeal space synovial sarcoma is a rare variant.
For example," said Kadoch, "a type of mutation called a chromosomal translocation in the gene encoding one of these newly identified subunits, SS18, is known to be the hallmark of a cancer called synovial sarcoma.
2), which results in the fusion of the SYT gene on chromosome 18 with the synovial sarcoma, X breakpoint 1 (SSX1)or synovial sarcoma, X breakpoint 2 (SSX2) gene on chromosome X, is a unique feature of synovial sarcoma and is extremely useful in distinguishing it from other sarcomatoid tumors of the lung and pleura.
It was not until the summer of 2009, when a lump developed on Rachel's shoulder and a CT scan and biopsy identified that she had synovial sarcoma - a rare form of cancer - and the tumour was the size of a large mug.
Malignant etiologies that should be a differential consideration include synovial sarcoma and synovial chondrosarcoma.
There are some reports of hypopharyngeal sarcomas such as angiosarcoma, liposarcoma and synovial sarcoma [1].
Immunohistochemical staining shows strong dot like or perinuclear vimentin staining and diffuse membranous staining for CD99 in all members of the Ewings/PNET group, although weaker CD99 staining may be seen in other "round blue cell tumours" including rhabdomyosarcoma, T cell lymphomas, synovial sarcoma and small cell neuroendocine tumours (11).
Synovial sarcoma is an uncommon malignant neoplasm of the somatic soft tissues which usually affects the extremities and limb girdles, but it also infrequently occurs in the neck and trunk (3)