synovial sarcoma


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syn·o·vi·al sar·co·ma

a rare malignant tumor of synovial origin, most commonly involving the knee joint and composed of spindle cells usually enclosing slits or pseudoglandular spaces that may be lined by radially disposed epitheliallike cells.

synovial sarcoma

A mesenchymal spindle cell tumour which comprises ±10% of all soft-tissue sarcomas. It is most common in young (age 20 to 40) males, and occurs most commonly around the large joints—knee, ankle, foot, 60% in the legs, 23% in upper extremity. However, it can go any place, as cases have been reported in the penis, lung, vulva, abdominal wall, etc.

Prognosis
50% 5-year survival; extensively calcified synovial sarcomas have a higher (84%) 5-year survival; 40% metastasise to lungs, bone-regional nodes.

Good prognostic factors
Children; < 5cm; <10 mitoses/10hpf; no necrosis; complete excision in first attempt.
 
Adverse prognosticators
Older age, larger size (especially, > 35 cm), necrosis, vascular invasion, high Ki-67 index, high-grade nuclei, poorly differentiated areas, known recurrence.

Synovial sarcoma, histologic types
Biphasic
• Distinct epithelial and spindle cell components.
 
DiffDx
Mesothelioma, carcinosarcoma.

Monophasic

DiffDx, Spindle cell type
Malignant peripheral-nerve sheath tumour, schwanoma, solitary fibrous tumour, fasciitis.

DiffDx, Glandular cell type
Any adenocarcinoma.

Poorly differentiated

DiffDx
Ewing sarcoma and other small round cell tumours.

synovial sarcoma

Surgery A mesenchymal malignancy that comprises ±10% of all soft tissue tumors; it is most common in young–age 20-40 ♂, knee, ankle, foot, etc Prognosis 50% 5-yr survival; extensively calcified SSs have a higher–84% 5-yr survival. See Sarcoma, Soft tissue tumors.
References in periodicals archive ?
It happened two years ago, just after Pete had been diagnosed with Synovial Sarcoma, a rare cancer in his foot, and told he would need to have a below-the-knee amputation.
* Adaptimmune Therapeutics PLC -- ADR (NASDAQ: ADAP)(announced initiation of trial dubbed SPEARHEAD-1 that is evaluating ADP-A2M4 SPEAR T cells for patients with synovial sarcoma or myxoid/round cell liposarcoma)
Adaptimmune Therapeutics has started its SPEARHEAD-1 trial with ADP-A2M4 SPEAR T-cells for patients with synovial sarcoma or myxoid/round cell liposarcoma.
It was then on August 20 last year Bernadette, who had been working as a clerk at Sean Graham bookies in Andersonstown , was told she had synovial sarcoma, a rare cancer which develops in cells around joints and tendons.
It was then on August 20 last year Bernadette, who had been working as a clerk at Sean Graham bookies in Andersonstown, was told she had synovial sarcoma, a rare cancer which develops in cells around joints and tendons.
The malignant mesenchymal lesions we encountered were synovial sarcoma, malignant fibrous histiocytoma etc.
In 2018, Adelardo was diagnosed with Synovial sarcoma in his right foot, a type of soft-tissue sarcoma that affects about one to three individuals in a million people.
Keywords: Immunohistochemistry, Mediastinum, Synovial Sarcoma.
The differential diagnosis for EMCS includes synovial sarcoma, malignant solitary fibrous tumor, Ewing sarcoma, and other small, round blue cell tumors, particularly in biopsy specimens.
Other authors reported the tumor being second to malignant fibrous histiocytoma [5-7] or synovial sarcoma [8, 9].
The study is the first programme under Immunocore's collaboration with GSK to proceed into clinical development and it will evaluate the safety and tolerability of IMCnyeso in patients with non-small cell lung cancer (NSCLC), bladder cancer, melanoma and synovial sarcoma, positive for NY-ESO-1 and/or LAGE-1A.
Primary chest wall tumors included synovial sarcoma in 7 patients (31.8%), carcinoma breast in 5 patients (22.7%), Dermatofibrosarcoma protuberans in 2 patients (9.1%), chondrosarcoma sternum in 1 patient (4.5%), Osteosarcoma of the sternum in 1 patient (4.5%), Ewings sarcoma in 3 patients (13.6%) and infection in 1 case (4.5%).