syndrome of inappropriate antidiuretic hormone secretion


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SIADH

Syndrome of inappropriate antidiuretic hormone secretion. A condition characterised by increased vasopressin/ADH secretion (despite low plasma osmolarity), water retention and dilutional hyponatraemia.
 
Aetiology
Addison’s disease, ACTH deficiency, AIDS, hypopituitarism, paraneoplastic hormone production (small cell carcinoma of lung, bronchogenic, pancreas, uterine, bladder or prostate), lymphoproliferative disorders, mesothelioma, thymoma, CNS disease (trauma, infection, chromophobe adenoma), metastases, lung disease (TB, pneumonia, PEEP ventilation), porphyria, drugs (e.g., chlorpropamide, vincristine, etc.).
 
Lab
Hypervolemia, hypouricaemia, decreased creatinine, hyponatraemia, natriuresis (urinary sodium > 20 mEq/L with decreased BUN), no symptoms of volume depletion, decreased maximum urinary dilution, increased ADH, normal renal and adrenal function.
 
Management
Corticosteroids to suppress ADH secretion.

syndrome of inappropriate antidiuretic hormone secretion

SIADH, aka dilutional hyponatremia
References in periodicals archive ?
Obermuller, "Endocrine testing for the syndrome of inappropriate antidiuretic hormone secretion (SIADH)," endotext, 2017, http://www.endotext.org.
Cases of life-threatening hypotonic encephalopathy and fatal cerebral edema demonstrated euvolemia with non-osmotic secretion of arginine vasopressin (AVP), fulfilling the essential diagnostic criteria for the syndrome of inappropriate antidiuretic hormone secretion (SIADH).
Hyponatremia in a neurosurgical patient: Syndrome of inappropriate antidiuretic hormone secretion versus cerebral salt wasting.
This educational activity is designed for nurses and other health care professionals who care for and educate patients regarding the syndrome of inappropriate antidiuretic hormone secretion (SIADH).
The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is one such adverse reaction to fluoxetine that is potentially life-threatening but readily reversible if recognized.

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