synaptosome


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syn·ap·to·some

(sin-ap'tō-sōm),
Membrane-bound sac containing synaptic vesicles that breaks away from axon terminals when brain tissue is homogenized under controlled conditions; such particles can be separated from other subcellular particles by differential and density gradient centrifugation.
[synapse + G. sōma, body]

synaptosome

/syn·ap·to·some/ (sin-ap´to-sōm″) any of the membrane-bound sacs that break away from axon terminals at a synapse after brain tissue has been homogenized in sugar solution; it contains synaptic vessels and mitochondria.

synaptosome

(sĭ-năp′tə-sōm′)
n.
Any of various sacs, composed of synaptic vesicles and mitochondria, that break away from axon terminals at a synapse after brain tissue has been homogenized under controlled conditions.

syn·ap′to·so′mal adj.

synaptosome

[sinap′təsōm′]
a presynaptic nerve terminal that has been separated from the rest of the neuron and isolated from homogenates of brain tissue. It appears as a membrane-bound structure containing synaptic vesicles.

syn·ap·to·some

(si-nap'tŏ-sōm)
Membrane-bound sac containing synaptic vesicles that breaks away from axon terminals when brain tissue is homogenized under controlled conditions; such particles can be separated from other subcellular particles by differential and density gradient centrifugation.
[synapse + G. sōma, body]
References in periodicals archive ?
The effects of alstonine [3H]DA uptake were assessed in synaptosomes prepared from striatal tissue obtained from mice treated acutely or for 7 days with alstonine.
Further evidence that dietary intake of BM leaf powder confers the prepubertal brain with additional capacity to cope up with neurotoxic prooxidants was obtained by exposing cortical/cerebellar synaptosomes of normal and BM fed mice to 3-nitropropionic acid (3-NPA).
This included the increased accumulation of dopamine in synaptosomes due to delayed efflux.
Brevetoxin B: chemical modifications, synaptosome binding, toxicity, and an unexpected conformational effect.
Valeriana officinalis: aqueous and ethanolic/aqueous root extracts of valerian were both found to contain GABA and this intrinsic content is believed to be responsible for the ability of both extracts to increase GABA release in rat synaptosomes.
Effect of age, gender, rat strain, and dietary restriction, on norepinephrine release from cardiac synaptosomes.
Brevetoxins, unique activators of voltage-sensitive sodium channels bind to specific sites in rat brain synaptosomes.
On the basis of these results, it was concluded that astaxanthin inhibits glutamate release from rat cortical synaptosomes through the suppression of presynaptic voltage-dependent Ca(2+) entry and MAPK signaling cascade.
Inhibitory effect of taurine on 4-amino-pyridine-stimulated release of labelled dopamine from striatal synaptosomes.
and Harris, RA Calcium--dependent 86 Rb efflux and ethanol intoxication: Studies of human red blood cells and rodent brain synaptosomes.
Figure 10, which summarises results obtained with isolated synaptosomes (20), shows that barbiturate directly inhibits the entry of calcium ions (triggered here by three distinct methods with essentially identical results), an effect which would (see above) reduce transmitter release from synaptic terminals of the kind from which these synaptosomes were obtained.