synaptosome

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syn·ap·to·some

(sin-ap'tō-sōm),
Membrane-bound sac containing synaptic vesicles that breaks away from axon terminals when brain tissue is homogenized under controlled conditions; such particles can be separated from other subcellular particles by differential and density gradient centrifugation.
[synapse + G. sōma, body]

synaptosome

(sĭ-năp′tə-sōm′)
n.
Any of various sacs, composed of synaptic vesicles and mitochondria, that break away from axon terminals at a synapse after brain tissue has been homogenized under controlled conditions.

syn·ap′to·so′mal adj.

syn·ap·to·some

(si-nap'tŏ-sōm)
Membrane-bound sac containing synaptic vesicles that breaks away from axon terminals when brain tissue is homogenized under controlled conditions; such particles can be separated from other subcellular particles by differential and density gradient centrifugation.
[synapse + G. sōma, body]
References in periodicals archive ?
(49) Over expression of Pr[P.sup.C] increases [Cu.sup.2+] uptake into cells, (50) while Pr[P.sup.C] knockout ([Prnp.sup.-/-]) mice show a lower synaptosomal [Cu.sup.2+] concentration than normal mice.
Cooper, "Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase," FEBS Letters, vol.
Marsden, "Effects of amphetamine isomers, methylphenidate and atomoxetine on synaptosomal and synaptic vesicle accumulation and release of dopamine and noradrenaline in vitro in the rat brain," Neuropharmacology, vol.
Suzuki et al., [57] have shown that the cholesterol synthesis was inhibited and the cholesterol content was reduced in the synaptosomal membranes of the brain tissue in the STZ-induced diabetic rats.
This drug potently and selectively inhibits synaptosomal reuptake of serotonin by binding to the 5-HT (5hydroxytryptamine) transporter in the neuronal membrane and blocking reuptake of 5-HT from the synapse into the presynaptic nerve terminal.
Synaptosomal Protein of 25 kDa (Snap25) Polymorphisms Associated with Glycemic Parameters in Type 2 Diabetes Patients.
High levels of synaptosomal Na(+)-Ca(2+) exchangers (NCX1, NCX2, NCX3) co-localized with amyloid-beta in human cerebral cortex affected by Alzheimer's disease.
2012) Naltrexone ([up arrow]) PDYN and ([down arrow]) PDYN in dorsolateral-PFC, synaptosomal OPRK1 OPRK1 in OFC and PDYN in receptor expression in hippocampus (Bazov et al.
(16,17) Tramadol, a nonopioid analgesic which inhibits 5-HT re- uptake and enhances synaptosomal concentration of 5-HT and noradrenaline, also inhibits shivering after the administration of general anesthesia.
Synaptosomal preparations were obtained from acute or subchronic treated mice.
Fetal life in Down syndrome starts with normal neuronal density but impaired dendritic spines and synaptosomal structure.