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(sin-ap'tō-fīs'in), [MIM*313475]
An integral membrane glycoprotein found in many types of active neurons; believed to form a hexamer that forms an ion channel and is involved in the uptake of neurotransmitters; synaptophysin is found in the membrane only after stimulation of the neurons.
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In the immunohistochemistry examination of the tumor, a strong homogeneous positive reaction with antibodies against chromogranin (Figure 2 D) and synaptophysin (Figure 3 A) was observed.
In terms of immunohistochemical assessment, the most commonly used markers are synaptophysin, Chromogranin and CD56, but other recently introduced markers such as ASH1 and NKX2.2 can be used.
Immunohistochemistry is useful in making this distinction (1).The chief and sustentacular cells of paragangliomas are immunoreactive to neuroendocrine marker stains, such as chromogranin and synaptophysin, but not to epithelial markers, such as cytokeratin (1, 2, 5).
suggest that the IHC panel for metastatic RCC should include PAX2 or PAX8 and RCC marker or CD10, with auxiliary markers for differential diagnoses.[9] In our case, the aforementioned subdiagnoses were excluded by IHC staining, as we observed negative staining for chromogranin and synaptophysin and positive staining for CD10 and PAX8.{Table 1}
The signet-ring cells were negative for synaptophysin, chromogranin A, and CD57 (PGP9.5).
Immuno-histochemistry was done on the biopsy sample subsequently and positive reactivity to chromogranin and synaptophysin confirmed neuroendocrine origin, and negative reactivity to CDX 2, PAX 8 and TTF 1 favored primary hepatic origin.
Immunohistochemical analysis demonstrated positivity for chromogranin A and synaptophysin in PCLC (Fig.
(9) Individual tumor cells are often round to oval with scant or moderate eosinophillic cytoplasm and pleomorphic nuclei with rhabdoid and epitheloid cells scattered at periphery.9 ESMC expresses neuroendocrine differentiation with strong immunopositivity for vimentin and synaptophysin (7) and weak or focal positivity for EMA and S-100.7 Myxoid matrix with lobulated neoplastic cells is also seen in chordoma, parachordoma, chordoid meningiomas, and myxopapillary ependymoma.
To prevent non-specific binding, blocking solution (Tris Buffered Saline, 0.1% Tween-20, 5% casein) was applied and the membranes were incubated overnight at + 4 [degrees]C with primary antibodies for TH (tyrosine hydroxylase) (mouse, monoclonal, 1:1000; T2928, Sigma Aldrich, USA), synaptotagmin 7 (rabbit, polyclonal, 1:1000; 105-173 Synaptic systems, Germany), synaptophysin (mouse, monoclonal, 1:1000; S5768, Sigma Aldrich, USA) and secretogranin 2 (mouse, monoclonal, 1:1000; SG-II 6B 1/3, ab20245, Abcam, USA) at different sessions.
Mouse anti-human synaptophysin, Dak-synap clone, Ready for use; Monocl.
Immunohistochemical studies showed staining for CD 56, Synaptophysin, Chromogranin, Cytokeratin and Enolase Neuron.
N49 M 65 4.0 Positive staining for 3 synaptophysin. Ki-67 3.2% N50 M 36 4.0 Positive staining for 3 synaptophysin.