Neuralstem believes that certain molecules such as NSI-189 stimulating the generation of new neurons and promoting synaptogenesis
in the hippocampus could potentially reverse the pathophysiology of the depression itself.
37) Additionally, vitamin D regulates intracellular calcium throughout the body and can down regulate voltage sensitive calcium channels, altering calcium flux that affects neurogenesis, synaptogenesis
, myelination, and neurotransmitter release in the brain.
2005) and participates in synaptogenesis
(Cohen-Cory et al.
Tchantchou F, Lacor PN, Cao Z, Lao L, Hou Y, Cui C, Klein WL, Luo Y Stimulation of neurogenesis and synaptogenesis
by bilobalide and quercetin via common final pathway in hippocampal neurons.
This key observation, along with other evidence supporting a role for hevin in synaptogenesis
and its presence at excitatory synapses, suggests that hevin is involved in the neuroplasticity underlying positive affect and motivation.
This section also covers synaptogenesis
during recovery from trauma and in the olfactory system and hippocampus.
Study suggest that CDK5/p35 play critical roles in neural migration, differentiation, and synaptogenesis
in immature neurons.
The cholesterol synthetic defect leads to defective synaptogenesis
seen in autism and schizophrenia.
b) Adapted from "Motor Learning-Dependent Synaptogenesis
Is Localized to Functionally Reorganized Motor Cortex," by J.
Single nucleotide polymorphisms] associated previously with different psychiatric disorders identified convergence of pathways in synaptogenesis
axonal guidance, and synaptic plasticity; and now calcium signaling, which is pivotal in the mechanisms of all these biological processes.
A window of vulnerability in rodents appears to occur during peak synaptogenesis
between postnatal day 7 and 30.
Subcellular localization suggested a possible role for synapsin III in the regulation of neurotransmitter release and synaptogenesis