Our work not only has the capacity to uncover novel aspects in the regulation of presynaptic autophagy and function, but it will also reveal mechanisms of synaptic dysfunction in models of neuronal demise and open new research lines on mechanisms of synaptic plasticity
Aptinyx's therapeutics are designed to enhance synaptic plasticity
, or strengthen the network for neural cell communication, a pathway that underlies multiple nervous system conditions.
In term of cognitive function, previous studies have shown that TEN enhanced learning and memory in both healthy and ovariectomized mice, in which one of the potential mechanisms is related to improve the basic synaptic transmission and synaptic plasticity
(Huang et al.
Calcium-chelation was shown to improve spatial learning and synaptic plasticity
in older animals.
Additional potential neuroprotective effects of curcumin and/or the curcuminoids include as an antidepressant; protection against aluminium induced neurotoxicity, ethanol-induced brain damage, sodium-arsenite toxicity, 3-nitorpropionic acid-induced toxicity, MPTP toxicity, traumatic brain injury, lead induced neurotoxicity, glutamate toxicity and brain focel ischemia; memory improvement by HIV glycoprotein; anti aging; reversal of amyloid pathology and ethanol induced neurotoxicity; and restoration of the synaptic plasticity
That process, known as synaptic plasticity
, is too time-consuming to account for the human mind's flexibility, he believes.
Writing in the journal Nature Medicine the US team, led by Dr Tony Wyss-Coray from Stanford University, said: "Our data indicate that exposure of aged mice to young blood late in life is capable of rejuvenating synaptic plasticity
and improving cognitive function.
Our findings suggest that green tea might increase the short-term synaptic plasticity
of the brain," said Prof.
One of the major functions of GluRs is the modulation of synaptic plasticity
, a property of the brain thought to be vital for memory and learning.
The NMDA receptor/ion channel complex: a drug target for modulating synaptic plasticity
One mechanism that may provide a link between stress-related psychiatric disorders and alcoholism is modification of synaptic plasticity
via neuroadaptation (figure 1) (Moonat et al.
SNAP-25 is highly expressed in the nerve cells of the adult brain and it is associated with regions of high synaptic plasticity