NYX-2925 is an oral, small-molecule NMDA receptor modulator that binds to a novel site on the NMDA receptor and enhances synaptic plasticity
to restore normal neural cell function.
Our research shows that combination treatment with the two compounds can promote resilience against stress-mediated depression-like phenotypes by modulating systemic inflammatory responses and brain synaptic plasticity
in a mouse model of depression," said Jun Wang, Associate Professor at Icahn School of Medicine at Mount Sinai.
is responsible for the storing of memories in the memory structures of the brain: During that process the communication between neurons is altered by means of a process called synaptic plasticity
, so that a memory is created.
Emotional dysregulation, reduced hippocampal/prefrontal synaptic plasticity
, anhedonia, inflammation, disordered body clock rhythms, and insulin resistance are all associated with chronic stress.
Glutathione peroxidase (GSH-Px) is present throughout the body, but it plays its greatest roles in cognitive function and synaptic plasticity
13] These mechanisms all serve to support LTP and synaptic plasticity
These waves cause changes in nerve tips letting our brain function - this process is called synaptic plasticity
and lets us learn and process information.
In the brain, the BDNF protein paly significant role in connections and communications between nerve-nerve cells (synopses) and helps in regulation of synaptic plasticity
, which is important for memory and learning.
Their topics include a theoretical model of state transition of CaM-dependent protein kinase II, the bi-directionality of synaptic pathways related to long-term potentiation and long-term depression, the uncertainty quantification of models related to synaptic plasticity
, and synaptic plasticity
in dementia: Alzheimer's disease and the role of calcium.
32,33) The accumulating evidences indicate that spines have modulatory functions in postsynaptic signal transduction and synaptic plasticity
Cortisol affects synaptic plasticity
in regionally-dependent and dose-dependent ways.
In previous studies, MMP-9 has been demonstrated to be mandatory in the central amygdala for formation of appetitive memory traces via synaptic plasticity
the structural and physiological alteration of synapses, the connections that facilitate communication between neurons.