Treatment with AXER-204 resulted in significant regrowth of nerve fibres and increased functionality -- including axonal regeneration, axonal sprouting and synaptic plasticity
-- even many months after injury or damage, with no toxicological findings.
In addition, d-methadone increased the expression of synaptic proteins and receptors critically involved in synaptic plasticity
. The poster presentation also highlighted results from two phase 1 studies showing that d-methadone exhibited a linear pharmacokinetic profile for a range of single dose and multiple dose parameters with no serious adverse events reported.
[Ca.sup.2+] acts as a second messenger and activates various calcium-dependent proteins, including calmodulin, calcineurin, protein kinase C, and [Ca.sup.2+]/calmodulin-dependent protein kinase II (CaMKII), all of which are crucial for synaptic plasticity
. (48),(49) Third, simultaneous activation of NMDA-Rs across multiple synapses in close spatial proximity along a dendritic segment can generate a non-linear effect on the local potential, termed "NMDA spikes" (Fig.
Calcium is an important intracellular messenger, triggers many cellular signaling pathways in neurons associated with differentiation and growth, exocytosis, synaptic transmission and synaptic plasticity
during learning and memory (2).
Changes in mitochondrial functions (Ca+ regulation, energy metabolism, and oxyradical production) play a crucial role in synaptic plasticity
. Moreover, age-related cognitive impairment, and presumably the synaptic plasticity
subservient learning and memory, is associated with structural abnormalities in mitochondria and oxidation of RNA and DNA [10,14].
"I think it's quite amazing that we are able to reprogram single neurons in the intact brain and witness in the living tissue the diversity of molecular mechanisms that allows these cells to integrate new functions through synaptic plasticity
," El-Boustani said.
Bacopa monnieri, commonly known as Brahmi, has been used in Ayurvedic medicine as a memory enhancer for many years; however, its effect on brain and synaptic plasticity
has not been well investigated.
Specifically, the researchers found that two grape derived compounds dihydrocaffeic acid (DHCA) and malvidin-3'-O-glucoside (Mal-gluc) can promote resilience in mouse models of depression by modulating inflammation and synaptic plasticity
One probable reason is that exercise augments cell proliferation, long-term potentiation, (4) and synaptic plasticity
(5) in animal brains.
Perforant-path stimulation is a classical in vivo model to study synaptic transmission, long-term synaptic plasticity
, and network excitability in the dentate gyrus .
Artificial sensation through stimulation - synaptic plasticity
- is responsible for the retaining memories in the brain.