The generation of a synapsin III knock-out mice provided the evidence of a unique function of this gene when compared to synapsin I and II, indicating a role in early axon development and the regulation of neurotransmitter release in mature synapses with evidence for decreased basal transmission at inhibitory synapses but not at excitatory synapses (34).
(13.) De Camilli P Harris SM Jr, Huttner WB, Greengard P Synapsin I (Protein I), a nerve terminal-specific phosphoprotein.
As GAD-65 antibody is associated with gluten sensitivity, it is conceivable that in some patients with gluten sensitivity, the anti-gliadin antibody response would affect both synapsin I activity, as well as reduction in GABA release, which may explain severe ataxia in some patients with gluten sensitivity.
Since synapsin is a neuronal phosphorprotein involved in the regulation of neurotransmitter release, the binding of anti-gliadin antibodies to synapsin may reveal clues about the potential pathogenic roles of the antibody and its association with extra-intestinal complications.