switch gene


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switch gene

a gene that causes the total genetic developmental system to change to a different developmental pathway.
References in periodicals archive ?
G0/G1 switch gene 2 (G0S2) was initially found to be differentially expressed in lymphocytes during lectin-induced switch from the G0 to G1 phase of the cell cycle [51, 52].
In their published research, a team led by senior author Kang Zhang, MD, PhD, chief of ophthalmic genetics, founding director of the Institute for Genomic Medicine and co-director of biomaterials and tissue engineering at the Institute of Engineering in Medicine, both at UC San Diego School of Medicine, used CRISPR/Cas9 to deactivate a master switch gene called Nrl and a downstream transcription factor called Nr2e3.
"Ash2l is important in epigenetics-changes in gene activity that do not involve alterations to the genetic code spelled out in DNA." In epigenetic processes, chemical groups attached either to DNA, or to DNA-associated proteins called histones, switch gene activity on or off.
it uses a common antibiotic, tetracycline, to switch gene activity on and off throughout the life of the organism, says Glenn I.
Biologists found that inflammatory signals activate 'Nuclear Factor kappa B' (NF-[eth][bar]B) proteins to start a 'clock' ticking, in which NF-[eth][bar]B proteins move backwards and forwards into and out of the cell nucleus, where they switch genes on and off.
The epigenome includes chemical tags like methyl groups that attach to DNA and histones to switch genes on and off to regulate protein expression.
Last year, scientists in California turned mouse skin cells directly into brain cells using proteins that switch genes on or off.
The regulatory machinery works when proteins called transcription factors bind to specific short sequences of DNA that flank the gene, called transcription factor binding sites, and by doing so, switch genes on and off.
Further work showed that the gene influencing levels of C-glyTrp could be modified by epigenetics, a process whereby environmental factors switch genes on or off and alter their activity.
These tags attach themselves to portions of the DNA, functioning to switch genes on and off.
Dr Simon Archer and his team at the University found that changes in the amount they had slept could switch genes on or off.
Dr Karsten Suhre, professor of physiology and biophysics and director of the college's Bioinformatics Core, led a team of researchers from institutions across the globe who studied how individual differences in lifestyles and health leave an imprint on a person's epigenome -- a series of chemical modifications to a person's genome that have the ability to switch genes 'on' or 'off'.