swainsonine


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swainsonine

a trihydroxylated indolizidine alkaloid found in Swainsona spp., Schizoctonia leguminicola and Astragalus spp. It is a potent α-mannosidase inhibitor and poisoning by it leads to accumulation of mannosidose in tissues.
References in periodicals archive ?
Swainsonine causes cellular accumulation of oligosaccharides due to inhibition of several important enzymes, resulting in cellular vacuolization and death in the central nervous system and in other systems (DE BALOGH et al.
Cancer chemotherapy Cis-diamminedichloroplatinum (II) Golgi a-mannosidase 11 [alpha]-Mannosidase inhibitor Astragalus lentiginosus Cell cycle Swainsonine
Effects of graded levels of bentonite on serum clinical profiles, metabolic hormones, and serum swainsonine concentrations in lambs fed locoweed (Oxytropis sericea).
Ipomoea carnea is a toxic plant due to the alkaloids swainsonine and calystegines, which causes animal production economic losses in Northeast Argentina.
N-glycosylation and complex glycan synthesis can be inhibited by specific compounds such as tunicamycin and swainsonine [8].
Feeding deterrency of some pyrrolizidine, indolizidine, and quinolizidine alkaloids towards pea aphid (Acyrthosiphon pisum) and evidence for phloem transport of indolizidine alkaloid swainsonine.
The toxin, swainsonine, can weaken and eventually kill not only cattle, but also horses, sheep, goats, and other animals that graze on the dozen or so rangeland plants commonly known as locoweeds, says ARS chemist Russell J.
fistulosa is a plant that contains the indolizidine alkaloid swainsonine, which causes a neurological disease characterized by lysosomal accumulation of oligosaccharides in ruminants, especially in goats.
Experimental swainsonine poisoning in goats ingesting Ipomoea sericophylla and Ipomoea riedelii (Convolvulaceae).
In order to investigate the effects and mechanisms of swainsonine in C6 glioma cells, we carry out correlated experiments in vitro and in vivo.
Identification of Swainsonine as a glycoside inhibitor responsible for Sida carpinifolia poisoning.