Also this treatment could increase the number of spermatogonia and sustentacular cells
The periphery of the cell nests or Zellballen is lined by spindle-shaped sustentacular cells
The researchers have been working with adult olfactory stem cells that give rise to the neurons that sense odors and other cells, such as sustentacular cells
, that support the neurons.
The presence of sustentacular cells
is associated with benign behaviour; however, this finding has poor specificity and cannot reliably rule out metastasis.
The sustentacular cells
surrounding the tumors nests demonstrate positivity for S100 immunostain, which might be lost in high grade tumors with sheeting architecture.
The presence of typical Zellballen pattern of arrangement of tumour cells surrounded by sustentacular cells
and fibrovascular stroma favour a diagnosis of pheochromocytoma (Fig.
Chromogranin A stain was positive in polygonal cells, S-100 was positive in flattened sustentacular cells
on immune histochemistry.
The key diagnostic features in this case include a trabecular growth pattern, sustentacular cells
surrounding nests of tumor cells, neuroendocrine features with copious cytoplasm, and nuclear expression of TTF-1.
Pathologic examination reveals a characteristic biphenotypic cell line composed of chief cells and sustentacular cells
with a peripheral fibrovascular stromal layer that are organized into a whorled (Zellballen) pattern.
Paragangliomas will show positivity for neuron-specific enolase, chromogranin A and synaptophysin as well as S100 protein positivity for sustentacular cells
and are negative for thyroglobulin and calcitonin.
were positive for S-100 protein (Figure 2C), but negative for high molecular cytokeratins, monoclonal CEA.
Phaeochromocytoma was finally excluded due to the presence of a basophilic cytoplasm and the obvious absence of S100 positive sustentacular cells