A,C) Differentiated BMMSCs that cultured with Sustentacular cell condition medium were positive for Mvh (after 1 week) and Scp3 (after 3 weeks) (green color) and nuclei were stained with DAPI (blue color).
Sustentacular cells are known as nurse or mother cells for Spermatogonial stem cells (SSCs) in testis.
On the other hand, different data were found for the karyometric study of sustentacular cells
Photomicrograph showing sustentacular cells
, which are immunoreactive for S100 (original magnification X20).
Sox10-positive sustentacular cells
in neuroendocrine carcinoma of the lung.
25) Pheochromocytoma has the characteristic Zellballen microscopic pattern, with well-defined nests of tumor cells supported by sustentacular cells
5,24) In contrast to the intraluminal polypoid mass for metastatic clear cell RCC of the gallbladder, paraganglioma appears as a small, well-circumscribed nodule protruding to the external surface of the gallbladder and is composed of chief and sustentacular cells
arranged in a zellballen pattern.
a) Positive in the peripherally situated sustentacular cells
Immunohistochemistry confirmed the presence of 2 cell populations: the chief cells stained with neuron-specific enolase and chromogranin, whereas the sustentacular cells
stained with S100 protein.
Paraganglioma is positive for neuroendocrine markers, such as synaptophysin and chromogranin A, and contains S100 protein-positive sustentacular cells
Scattered S100positive sustentacular cells
were seen at the periphery of the cell nests.
Retroperitoneal paragangliomas have a "zellenballen" architecture with S100-positive sustentacular cells