sustained virological response


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sustained virological response

Abbreviation: SVR
In the treatment of chronic hepatitis C, having no detectable viral RNA in the blood 6 months after the completion of antiviral therapy. SVR is evidence of disease remission, and in many people, of cure.
See also: response
References in periodicals archive ?
Sustained virological response to antiviral therapy improves survival rate in patients with recurrent hepatitis C virus infection after liver transplantation.
It was found that the patients in the responder group had much better laboratory parameters i.e lower ALT, AFP and higher albumin as compared to the non responders and relapsers which strengthens the notion that patients who achieve sustained virological response have a much better outcome as compared to the other two groups.
"These clinical results combined with earlier preclinical work demonstrating additive or synergistic activity with both approved and investigational agents suggest that in a combination regimen, SCY-635 may improve rates of sustained virological response."
Lower risk of hepatocellular carcinoma and improved survival in patients with HCV related cirrhosis with sustained virological response. Hepatology 2008; 48: 264.
Professor Chung presented data from step 3 of the SLAM-C study [9], which examined the sustained virological response (SVR) to a total of 72 weeks of pegylated interferon and weight-based ribavirin in those patients achieving an early virological response (EVR).
On the other hand, although the sustained virological response rate in this study was lower than that with IFN-[alpha] and ribavirin, a higher rate may be obtained by extending the treatment period beyond 8 weeks, because ETR was achieved in 16 (89%) of our 18 patients.
"In view of the high sustained virological response and excellent tolerability achieved with DAAs, it seemed highly plausible to envision reductions in chronic HCV infection--related complications with these drugs," they said in reference to the study by Carrat and colleagues.
KEYWORDS: Direct Acting Antiviral Agents, Hepatocellular carcinoma, Sustained Virological Response.
Sustained virological response in special populations with chronic hepatitis C using interferon-free treatments: a systematic review and meta-analysis of observational cohort studies.
Objective: To compare metformin and pioglitazone with standard interferon and ribavirin in achieving sustained virological response in chronic hepatitis C patients.
Eradicating HCV can prevent decompensation of cirrhosis, HCC, and death.[1] The availability of direct-acting antiviral agents (DAAs) has significantly increased sustained virological response rates and decreased the complexity and adverse effects of HCV treatment.
Sustained virological response rates with antiviral therapy are not different between patients with chronic hepatitis C with/without chronic HBV infection (12).