susceptibility gene


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susceptibility gene

A gene that increases a person's likelihood of contracting a heritable illness.
See also: gene
Medical Dictionary, © 2009 Farlex and Partners
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The genes encoding GABR subunits represent major candidates for idiopathic generalised epilepsy susceptibility genes because of the widespread distribution of GABRs in the CNS, their ability to produce postsynaptic inhibition and their potential modulation by clinically important anticonvulsant drugs including benzodiazepines and barbiturates.
ASSOCIATION ANALYSIS OF [gamma]2 SUBUNIT OF [gamma]-AMINOBUTYRIC ACID TYPE- A RECEPTOR (GABRG2) AND LEUCINE-RICH GLIOMA-INACTIVATED 4 GENE (LGI-4) POLYMORPHISMS WITH IDIOPATHIC EPILEPSIES AND FEBRILE SEIZURES
Frequency of germline mutations in 25 cancer susceptibility genes in a sequential series of patients with breast cancer.
Who needs breast cancer genetics testing? Identifying patients who are appropriate candidates for breast cancer genetics testing is a key step toward prevention and value-based care
The NRG1gene is identified as a susceptibility gene for schizophrenia by using association methodologies based on microsatellite markers, detecting SNPs.
Association between a single nucleotide polymorphism in neuregulin-1 and schizophrenia in Pakistani patients
TGFB1 as a susceptibility gene for high myopia: a replication study with new findings.
TGFB1 and LAMA1 gene polymorphisms in children with high myopia
Considering the growing number of PHEO susceptibility genes and the well-established genotype-phenotype correlations for some of these gene mutations [3, 22], it is recommended that clinicians follow an algorithm based on the phenotype when requesting a genetic analysis [22, 23].
A Clinical Roadmap to Investigate the Genetic Basis of Pediatric Pheochromocytoma: Which Genes Should Physicians Think About?
Of note, this patient is a young adult of 26 years old, and the presence of a germline variant in a known cancer susceptibility gene may suggest that the PCC in this patient could be the first clinical expression of a hereditary disease still undefined.
Whole Exome Sequencing Uncovers Germline Variants of Cancer-Related Genes in Sporadic Pheochromocytoma
However, in recent years, ring finger protein 213 ( RNF213 ) was identified as a susceptibility gene among East Asian populations,[sup][1],[6] which resulted in a shift of people's attention to the relevant genetic factors.
Role of Ring Finger Protein 213 in Moyamoya Disease
In 2003, we reported peptidylariginine deiminase type 4 (PADI4) as a susceptibility gene for RA in a Japanese population.
Genetic studies of rheumatoid arthritis
Only a small percentage of women inherit the same faulty gene, known as BRCA1 -- the name stands for breast cancer susceptibility gene. These mutations are most commonly found in women of Eastern European Jewish descent, though other groups, including the Norwegian, Dutch and Icelandic, also have slightly higher rates of these mutations.
Angelina Jolie undergoes further preventive surgery
Tavtigian said originally, the gene we are currently studying, called RINT1, was not considered a human cancer susceptibility gene. But then we discovered there was a two- to three-fold increase in risk for breast cancer in families that carry a mutation in that gene.
Blame 4 new genes for upping familial breast cancer risk
Because of a susceptibility gene, emerging and getting rampant H7N9 flu virus may only infect residents of China.
Made for China? Research Says H7N9 Flu Virus Confined Only to Chinese
However, apart from RNaseL-, ElaC2-, MSR1-genes, there are not other identified high-risk genetic variants which might be considered responsible for hereditary PC, moreover suggesting that familial PC is a genetically heterogeneous disease, many gene loci rather than a specific major susceptibility gene predisposing to it.
Hereditary/familial versus sporadic prostate cancer: few indisputable genetic differences and many similar clinicopathological features

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