survivin

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survivin

(sur-vī'v'in),

Human gene encoding a unique IAP apoptosis inhibitor. Survivin is present in fetal tissues, but is undetectable in adult tissues. It is, however, expressed in transformed cell lines and in the most common types of human cancer (that is, lung, colon, pancreas, prostate, breast) as well as in high-grade non-Hodgkin lymphomas.

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IMV's lead candidate, DPX-Survivac, is a T cellactivating immunotherapy that combines the utility of the platform with a target: survivin. IMV is currently assessing DPX-Survivac as a monotherapy in advanced ovarian cancer, as well as a combination therapy in multiple clinical studies with Merck.

IMV Inc. to Present at upcoming Investor Conferences

To have a relatively thorough toxicity analysis of DMSA/[Ag.sub.2]S NIR QDs, the MTT and neutral red uptake (NRU) assays were performed to evaluate the potential cytotoxicity; the comet assay was performed to assess the potential genotoxicity; the real-time polymerase chain reaction (RT-PCR) technique was used to evaluate the regulation of mRNA expression of tumor suppressor gene (p53), apoptotic genes (caspase-3, caspase-9, and Bax) and anti-apoptotic genes (Bcl-2 and survivin).

An In Vitro Study on the Cytotoxicity and Genotoxicity of Silver Sulfide Quantum Dots Coated with Meso-2,3-dimercaptosuccinic Acid/Mezo-2,3-dimerkaptosuksinik Asitle Kaplanmis Gumus Sulfit Kuantum Noktalarinin Sitotoksisitesi ve Genotoksisitesi Uzerine Bir In Vitro Calisma

These patients have shown the best survivin specific T cell responses to DPX-Survivac among the analysed samples.

New Phase 2 Clinical Trial Results Continue to Demonstrate Potential Clinical Benefit of IMV's DPX-Survivac in Combination with US Merck's Keytruda in Patients with DLBCL

(39) observed that high-dose vincristine induced concomitant overexpression of P-gp and survivin.

Cytotoxic Effects of Some Flavonoids and Imatinib on the K562 Chronic Myeloid Leukemia Cell Line: Data Analysis Using the Combination Index Method

MicroRNA-203 Is a Prognostic Indicator in Bladder Cancer and Enhances Chemosensitivity to Cisplatin via Apoptosis by Targeting Bcl-w and Survivin. Plos One 2015;10:e0143441.

The Diagnostic and Prognostic Significance of MicroRNA-21 in Non-muscle Invasive Bladder Tumors

Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced b-catenin/Tcf-Lef dependent transcription.

VEGF-A and VEGFR2 Expression in Chicken Myocardium Treated with Acetylsalicylic Acid (AAS)/ Expresion de VEGF-A y VEGFR2 en Miocardio de Pollos Tratados con Acido Acetilsalicilico (AAS)

During canalization, apoptosis of surrounding epithelium is prevented by NF-KB, Bcl2, and Survivin which are anti-apoptotic proteins.9 Both blood vessels and nerves also start to develop around the developing gland.12 In addition to initial bud formation, Shh has a role in lumen formation.

COMPARATIVE ANATOMY AND MOLECULAR MECHANISMS INVOLVED IN RODENT SALIVARY GLAND DEVELOPMENT

Survivin overexpression in hepatocellular carcinoma is associated with p53 dysregulation.

Fibrolamellar Carcinoma: A Concise Review

Furthermore, no two cancer patients have the same BcL2\Bax ratio or even the same level of survivin, an inhibitor of apoptosis.

How to Approach the Cancer Patient, Diagnosis, and Treatment

It is known that Ki67, P53 (11,22), EGFR (23), survivin, and PCNA are related to gallbladder cancer (24).

Pathogenesis of gallbladder adenomyomatosis and its relationship with early-stage gallbladder carcinoma: an overview

Notch-1 signaling facilitates survivin expression in human non-small cell lung cancer cells.

Human bronchial epithelial cells as a good control for evaluation potential therapeutic Notch signaling in non-small cell lung cancer

Recent studies have shown that survivin controls the expression of this gene, which can reduce the viability of cancer cells and inhibit the tumor growth (22).