IMV's lead candidate, DPX-Survivac, is a T cellactivating immunotherapy that combines the utility of the platform with a target:
survivin. IMV is currently assessing DPX-Survivac as a monotherapy in advanced ovarian cancer, as well as a combination therapy in multiple clinical studies with Merck.
To have a relatively thorough toxicity analysis of DMSA/[Ag.sub.2]S NIR QDs, the MTT and neutral red uptake (NRU) assays were performed to evaluate the potential cytotoxicity; the comet assay was performed to assess the potential genotoxicity; the real-time polymerase chain reaction (RT-PCR) technique was used to evaluate the regulation of mRNA expression of tumor suppressor gene (p53), apoptotic genes (caspase-3, caspase-9, and Bax) and anti-apoptotic genes (Bcl-2 and
survivin).
These patients have shown the best
survivin specific T cell responses to DPX-Survivac among the analysed samples.
(39) observed that high-dose vincristine induced concomitant overexpression of P-gp and
survivin.
MicroRNA-203 Is a Prognostic Indicator in Bladder Cancer and Enhances Chemosensitivity to Cisplatin via Apoptosis by Targeting Bcl-w and
Survivin. Plos One 2015;10:e0143441.
Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced b-catenin/Tcf-Lef dependent transcription.
During canalization, apoptosis of surrounding epithelium is prevented by NF-KB, Bcl2, and
Survivin which are anti-apoptotic proteins.9 Both blood vessels and nerves also start to develop around the developing gland.12 In addition to initial bud formation, Shh has a role in lumen formation.
Survivin overexpression in hepatocellular carcinoma is associated with p53 dysregulation.
Furthermore, no two cancer patients have the same BcL2\Bax ratio or even the same level of
survivin, an inhibitor of apoptosis.
It is known that Ki67, P53 (11,22), EGFR (23),
survivin, and PCNA are related to gallbladder cancer (24).
Notch-1 signaling facilitates
survivin expression in human non-small cell lung cancer cells.
Recent studies have shown that
survivin controls the expression of this gene, which can reduce the viability of cancer cells and inhibit the tumor growth (22).