survivin


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survivin

(sur-vī'v'in),
Human gene encoding a unique IAP apoptosis inhibitor. Survivin is present in fetal tissues, but is undetectable in adult tissues. It is, however, expressed in transformed cell lines and in the most common types of human cancer (that is, lung, colon, pancreas, prostate, breast) as well as in high-grade non-Hodgkin lymphomas.
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IMV's lead candidate, DPX-Survivac, is a T cellactivating immunotherapy that combines the utility of the platform with a target: survivin. IMV is currently assessing DPX-Survivac as a monotherapy in advanced ovarian cancer, as well as a combination therapy in multiple clinical studies with Merck.
To have a relatively thorough toxicity analysis of DMSA/[Ag.sub.2]S NIR QDs, the MTT and neutral red uptake (NRU) assays were performed to evaluate the potential cytotoxicity; the comet assay was performed to assess the potential genotoxicity; the real-time polymerase chain reaction (RT-PCR) technique was used to evaluate the regulation of mRNA expression of tumor suppressor gene (p53), apoptotic genes (caspase-3, caspase-9, and Bax) and anti-apoptotic genes (Bcl-2 and survivin).
MicroRNA-203 Is a Prognostic Indicator in Bladder Cancer and Enhances Chemosensitivity to Cisplatin via Apoptosis by Targeting Bcl-w and Survivin. Plos One 2015;10:e0143441.
Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced b-catenin/Tcf-Lef dependent transcription.
During canalization, apoptosis of surrounding epithelium is prevented by NF-KB, Bcl2, and Survivin which are anti-apoptotic proteins.9 Both blood vessels and nerves also start to develop around the developing gland.12 In addition to initial bud formation, Shh has a role in lumen formation.
Survivin overexpression in hepatocellular carcinoma is associated with p53 dysregulation.
Furthermore, no two cancer patients have the same BcL2\Bax ratio or even the same level of survivin, an inhibitor of apoptosis.
It is known that Ki67, P53 (11,22), EGFR (23), survivin, and PCNA are related to gallbladder cancer (24).
Notch-1 signaling facilitates survivin expression in human non-small cell lung cancer cells.
Recent studies have shown that survivin controls the expression of this gene, which can reduce the viability of cancer cells and inhibit the tumor growth (22).