survivin


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survivin

(sur-vī'v'in),
Human gene encoding a unique IAP apoptosis inhibitor. Survivin is present in fetal tissues, but is undetectable in adult tissues. It is, however, expressed in transformed cell lines and in the most common types of human cancer (that is, lung, colon, pancreas, prostate, breast) as well as in high-grade non-Hodgkin lymphomas.
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Purpose: The role of survivin, an inhibitor of apoptosis protein, in TIIA-induced apoptosis has never been addressed before and hence was the primary goal of this study.
They have all clearly accumulated evidence demonstrating their efficacy to induce apoptosis by modulation of the P53 independent pathway, BAX, BAK, targeting the antiapoptotic proteins, Bcl-2, and survivin gene so as to potentialize a chemotherapy/radiation regimen.
Survivin is a new human gene encoding a structurally unique inhibitor of apoptosis proteins (IAP), apoptosis inhibitor, and plays an important role in the hyperplastic growth of tissues and tumors.
Levels of many STAT3-regulated gene products, including Bcl-2, cyclin D1, and survivin, were also reduced in SFN-treated cells.
Survivin is an inhibitor of apoptosis protein and a key regulator of programmed cell death and cell cycle progression.
The location of a protein called survivin may influence whether pancreatic cancer cells are susceptible to chemotherapy after surgery, researchers led by Barbara Burtness of Fox Chase Cancer Center in Philadelphia reported April 1.
Comparison of pHH3, Ki-67, and survivin immunoreactivity in benign and malignant melanocytic lesions.
Research and Development Enzon's research and development pipeline consists of the following programs: PEG-SN38, HIF-1 alpha antagonist, survivin antagonist and an additional six mRNA antagonists utilizing the LNA technology.
It was reported that survivin (SVN) is an essential antiapopotic gene and is expressed in pre-implantation mouse embryos in all stages of development by inhibiting an apoptotic pathway involving caspases (Kawamura et al.
Keratinositlerde survivin ekspresyonunda artis (12,13), Bcl-xL ekspresyonunda artis (14) ve interlokin (IL)-15 duzeylerinde artis (15) psoriasiste apoptozisin azaldigi yonundeki bulgular arasindadir (12-15).
Overcoming intrinsic radioresistance: survivin as a target