surrogate marker


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Related to surrogate marker: bioequivalence trial

surrogate marker

EBM
A parameter (e.g., diastolic blood pressure) used to assess a drug's biological activity, which may serve as indicator of efficacy of a therapeutic agent, rather than a more serious but less common clinical endpoint, such as death.

surrogate marker

Lab medicine A parameter or measured to detect a pathologic condition when a more specific test doesn't exist, is impractical or not cost-effective; surrogate testing has been used for non-A, non-B hepatitis, measuring ALT and antibodies to HBV core antigen–anti-HBc and HC

surrogate marker

An indirect indicator of a disease state or of its response to therapy. Such markers often include laboratory tests thought to represent clinical progress accurately. For example, in diabetes mellitus, the glycosylated hemoglobin level is used as a marker of glycemic control; in AIDS the level of HIV RNA is used as a marker of disease progression.
See also: marker
References in periodicals archive ?
The feasibility of using these parameters as low cost surrogate markers instead of CD4 count in assessing the progression of the disease was finally evaluated.
In HIV clinical research, the study endpoints are usually a change in surrogate markers.
In the early 1990s, activist pressure lead to reforms at the FDA that allowed for the accelerated approval of therapies for life-threatening conditions if 1) there were few effective options to treat that condition and 2) if there were surrogate markers (see p.
Raloxifene protected against breast cancer in women having surrogate markers indicative of low lifetime estrogen exposure but reduced risk by an even greater margin in those with high lifetime estrogen exposure.
Why, then, can't we solve this problem by developing an immune-based surrogate marker, like viral load for antiretrovirals?
Tooth loss is considered a surrogate marker for periodontitis, a common chronic inflammatory process involving the gums and other tooth-supporting structures.
Whether nevus development is directly in the pathway for melanoma development or a surrogate marker for UV-induced skin damage and/or genetic susceptibility to melanoma, our results suggest that tanning avoidance should be considered as a measure for the reduction of melanoma risk in this population.
CHICAGO -- An assay to calculate circulating tumor cells may be superior to PSA as a surrogate marker for survival in men treated for castration-refractory prostate cancer, according to a study presented at the annual meeting of the American Society of Clinical Oncology.
The FDA based its approval on the results of 3 surrogate marker studies.
It must be a surrogate marker for something that we don't understand," Dr.
1] Although it relied on relatively limited surrogate marker data, and although it acknowledged the technical deficiencies of resistance tests, the panel nevertheless recommended the use of these assays in a variety of clinical scenarios.