Structure, genetics and function of the pulmonary associated surfactant protein A and D: The extra-pulmonary role of these C type lectins.
Serum surfactant protein A levels in healthy individuals are increased in smokers.
KEYWORDS: BMI, COPD, ELISA, FEV, FEV1,
Surfactant protein A.
Saenz et al., "
Surfactant protein A prevents IFN-[gamma]/IFN-[gamma] receptor interaction and attenuates classical activation of human alveolar macrophages," The Journal of Immunology, vol.
Surfactant protein A: A key player in lung homeostasis.
In recent years, experimental studies have emphasized that specific pulmonary bioindicators considered to be secreted from deteriorated lung tissue, such as
surfactant protein A (SP-A), surfactant protein D (SP-D), Krebs von den Lungren-6 (KL-6), and Clara cell protein (CC-16), are effective in determining lung deterioration severity (29-31).
Among the shared proteins were some of the most prominent blood and BAL proteins: albumin, serotransferrin,
surfactant protein A (SP-A), [[alpha].sub.1]-antitrypsin, and immunoglobulins (13).
Surfactant protein A (SP-A) may regulate the secretion and exocytosis of surfactant from the type II cell, as well as the re-uptake of surfactant for recycling and re-use.
Effect of hydroxylation and N187-linked glycosylation on molecular and functional properties of recombinant human
surfactant protein A. Biochemistry 42:9532-9542.
Hallman, "Association between the
surfactant protein A (SP-A) gene locus and respiratory-distress syndrome in the Finnish population," American Journal of Human Genetics, vol.
Human
surfactant protein A (SP-A) may play a role in inflammation by modulating cytokine production by macrophages.