surfactant deficiency


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surfactant deficiency

Inadequate production of SURFACTANTS so that lung alveoli fail to remain adequately open. Severe cases (fatal surfactant deficiency) in newborns has recently been shown to be caused by various mutations of the ABCA3 gene.
References in periodicals archive ?
About 50 years ago, the importance of primary surfactant deficiency in the pathogenesis of neonatal RDS was found by Avery and Mead (4).
ABCA3 gene mutations in newborns with fatal surfactant deficiency.
First, neonatal RDS is a partial, not a total, surfactant deficiency.
A new oxygen-bearing lubricant, called perflubron, has been tested on 13 premature infants with severe surfactant deficiency.