surfactant deficiency


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surfactant deficiency

Inadequate production of SURFACTANTS so that lung alveoli fail to remain adequately open. Severe cases (fatal surfactant deficiency) in newborns has recently been shown to be caused by various mutations of the ABCA3 gene.
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About 50 years ago, the importance of primary surfactant deficiency in the pathogenesis of neonatal RDS was found by Avery and Mead (4).
The use of surfactant in the neonatal period- the known aspects, those still under research and those which need to be investigated further
ABCA3 gene mutations in newborns with fatal surfactant deficiency.
Update in nonneoplastic lung diseases
First, neonatal RDS is a partial, not a total, surfactant deficiency.
Is there evidence for a mortality difference between exogenous surfactant preparations in neonatal RDS?
A new oxygen-bearing lubricant, called perflubron, has been tested on 13 premature infants with severe surfactant deficiency.
Breathing a life-Sustaining liquid

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