Surfactant deficiency | definition of surfactant deficiency by Medical dictionary
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surfactant deficiency Inadequate production of SURFACTANTS so that lung alveoli fail to remain adequately open. Severe cases (fatal surfactant deficiency) in newborns has recently been shown to be caused by various mutations of the ABCA3 gene.
References in periodicals archive
About 50 years ago, the importance of primary surfactant deficiency
in the pathogenesis of neonatal RDS was found by Avery and Mead (4).
ABCA3 gene mutations in newborns with fatal surfactant deficiency
First, neonatal RDS is a partial, not a total, surfactant deficiency
A new oxygen-bearing lubricant, called perflubron, has been tested on 13 premature infants with severe surfactant deficiency