suramin


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Related to suramin: Melarsoprol

suramin

 [soo´rah-min]
an antifilarial and antiprotozoal agent used as the hexasodium salt in prophylaxis and treatment of early stages of African trypanosomiasis and sometimes onchocerciasis. Because of its toxicity it must be used with care.

suramin

A derivative of urea which has currency as an antiparasitic and been used to manage trypanosomiasis and onchocerciasis. Suramin was evaluated by the US National Cancer Institute for managing prostate cancer, but was dropped from its research in 2008.

Suramin has been used by alternative health practitioners as a cancer therapy, based on its ability to block enzyme activity and the production of growth factors. It has been used for leukaemia, as well as cancers of the adrenal cortex, breast, kidney and prostate; its effect may be enhanced by adding tumour necrosis factor and/or interferon-gamma to the therapeutic regimen.

suramin

a trypanocidal agent that is also toxic, causing degeneration of the liver, kidney and adrenal glands. It is also an inhibitor of reverse transcriptase, some types of growth factors, and causes suppression of the adrenal cortex, leading to investigations of its usefulness in the treatment of immunodeficiency infection in humans and cats, cancer and hyperadrenocorticism.
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The treatment results showed that Suramin was the most effective drug curing 75% Trypanosomiasis cases, Isometamidium chloride and Diminazine di aceturate cured 50% and 37.
THE INCIDENCE OF TRYPANOSOMIASIS IN THARI CAMELS AND EFFICACY OF VARIOUS DRUGS
The aim of this study was to investigate the effects of matriptase activation on intestinal epithelial integrity in porcine nontumorigenic nonpolarized and differentiated IPEC-J2 cells cultured on membrane insert after estimation of cell cytotoxic properties of the applied matriptase activators, S1P and suramin.
Reinforced Epithelial Barrier Integrity via Matriptase Induction with Sphingosine-1-Phosphate Did Not Result in Disturbances in Physiological Redox Status
Effect of suramin on proliferation and migration of lens epithelial cells in vitro.
Prospective randomised comparative study of the effects of 0.06% trypan blue dye as against 0.03% trypan blue dye after cortical cleaving hydro-dissection in an effort to impede the formation of posterior capsular Opacification (PCO)
However, the biological and behavioral benefits of suramin were not permanent, nor preventive.
Century-old drug approved for sleeping sickness may help treat autism: Study
volvulus could be susceptible to the same drug, such as suramin (14,15).
Effect of ivermectin on Trypanosoma brucei brucei in experimentally infected mice
2005) The use of suramin, an antifibrotic agent, to improve muscle recovery after strain injury.
Does single intramuscular application of autologous conditioned plasma influence systemic circulating growth factors?
A 100-mg test dose of suramin was well tolerated by the patient; however, the first full treatment dose was complicated by circulatory collapse and bronchoconstriction, which required administration of hydrocortisone and chlorphenamine and immediate discontinuation of the suramin infusion.
Multiorgan dysfunction caused by travel-associated African trypanosomiasis
1) It is less effective than suramin against Trypanosoma brucei rhodensiense and is also an ineffective treatment for the encephalitic stage of trypanosomiasis.
Trypanosoma brucei infection in a HIV positive Ugandan male
Antifibrotic effects of suramin in injured skeletal muscle after laceration.
Arsenic inhibits myogenic differentiation and muscle regeneration
To inhibit fibrosis formation following severe injury, attributed in large part to the secretion of transforming growth factor (TGF)- [beta] 1 [10], researchers have investigated the administration of TGF-[beta]1 specific inhibitors, such as relaxin [11], decorin [12], and suramin [13-15].
Regenerative rehabilitation: a call to action
12) effective against microfilaria Adjunctive doxycycline sterilises female worm Add systemic steroids in cases of eye involvement Suramin for adult worms Loiasis (Fig.
Parasites and the skin: parasitic infections may be confined to the skin or may have skin involvement as part of their pathology
For the treatment of East African sleeping sickness, only suramin and melarsoprol are used in the first and second stage of the disease, respectively.
Treatment and follow-up using microscopy and polymerase chain reaction in East African sleeping sickness: a case report

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