supraphysiologic

(redirected from supraphysiological)

su·pra·phys·i·o·log·ic

, supraphysiological (sū'pră-fiz'ē-ō-loj'ik, -loj'i-kăl),
Denoting any dose (of a chemical agent that either is or mimics a hormone, neurotransmitter, or other naturally occurring agent) that is larger or more potent than would occur naturally, or the effects of such a dose. Compare: homeopathic (2), pharmacologic (2), physiologic (4).

supraphysiologic

adjective Endocrinology Referring to administration of hormones or other substances that are normally present in the circulation, in doses in excess of those normally produced by the body. Cf Homeopathic, Pharmacologic, Physiologic.

supraphysiologic

, supraphysiological (soo″pră-fiz″ē-ŏ-loj′ik) (-loj′ĭ-kăl)
Exceeding what is normally found in healthy individuals. The term is usually used to refer to a hormone or medication given in a stronger dose than the amount the body can produce on its own.
References in periodicals archive ?
2] [less than or equal to] 1 is due to a combination of a high number of follicles and a supraphysiological FSH drive (45).
BPS, mostly at supraphysiological doses (micromolar to millimolar), has been reported to have genomic estrogenic activities in heterologous cell lines (Grignard et al.
In patients who are not vitamin B12 deficient, treatment efficacy usually seems to depend on the attainment of supraphysiological serum concentrations, concentrations that can be achieved only by parenteral administration.
ZFN-Mediated In Vivo Genome Editing Results in Supraphysiological Levels of Lysosomal Enzymes Deficient in Hunter and Hurler Syndrome and Gaucher Disease -- Abstract #479 Session: Gene Editing and Gene Regulation II Oral Presentation -- Friday, May 15, 2015
A test kit containing supraphysiological interferences has recently been commercialized for this study (Assurance Interference Test Kit, Sun Diagnostics).
One randomized trial found that supraphysiological doses of vitamin D were not better than physiological doses at improving cognition in AD.
In summary, it can be speculated that such a limited and fixed spatial recruitment and such a synchronous and supraphysiological temporal recruitment in neighboring fibers (Maffiuletti, 2010) provoke an exaggerated mechanical stress that could induce muscle damage (Jubeau et al.
The effects of supraphysiological doses of testosterone on muscle size and strenght in normal men.
Supraphysiological estrogen levels during ovarian stimulation are regarded by some clinicians as prohibitive, particularly in patients with hormone-dependent cancers (48); the use of letrozole, however, is recommended during controlled ovarian hyperstimulation in patients with hormone-dependent cancers 1491; 4.
From an October 2010 conference in London, 18 articles consider such topics as stem cells in endometrium and their role in the pathogenesis of endometriosis, ovarian cryopreservation strategies and the find control of ovarian follicle development in vitro, strategies to improve embryo implantation to supraphysiological rates, intensive care treatment of ovarian hyperstimulation syndrome, and long-term progestin-only contraception in humans versus animal models.
In addition, previous studies have also demonstrated that in vivo studies and also in vitro organ bath studies demonstrate the effects at only supraphysiological levels (1, 7, 8).
Supraphysiological reactive oxygen species (ROS) levels have been reported in men with varicocele and is one of the potential aetiological factors in varicocele mediated deterioration in sperm concentration, motility and morphology (3-5).