supraphysiologic

(redirected from supraphysiological)

su·pra·phys·i·o·log·ic

, supraphysiological (sū'pră-fiz'ē-ō-loj'ik, -loj'i-kăl),
Denoting any dose (of a chemical agent that either is or mimics a hormone, neurotransmitter, or other naturally occurring agent) that is larger or more potent than would occur naturally, or the effects of such a dose. Compare: homeopathic (2), pharmacologic (2), physiologic (4).
Farlex Partner Medical Dictionary © Farlex 2012

supraphysiologic

adjective Endocrinology Referring to administration of hormones or other substances that are normally present in the circulation, in doses in excess of those normally produced by the body. Cf Homeopathic, Pharmacologic, Physiologic.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

supraphysiologic

, supraphysiological (soo″pră-fiz″ē-ŏ-loj′ik) (-loj′ĭ-kăl)
Exceeding what is normally found in healthy individuals. The term is usually used to refer to a hormone or medication given in a stronger dose than the amount the body can produce on its own.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
(10,11,12) The resulting serum profile provided by bid dosing from the metered-dose pump dispenser (Fig 1) is believed to provide a unique combination of advantages related to safety and efficacy, including: (i) no touch administration that avoids transference; (ii) fast/easy self-administration requiring only about 10 seconds per dose; (iii) very low risk of experiencing supraphysiological T even at the maximum recommended daily dose due to a divided dose (13); and, (iv) retention of gonadotropin feedback with potential retention of sperm count and the possibility of lessening of testicular atrophy.
[5] At supraphysiological ICS doses, 50% of children can be expected to develop HPAS, [21] while at physiological doses (i.e.
Chen's team reported data indicating AGU gene therapy resulted in dose-dependent, complete or near-complete elimination of toxic substrate in central and peripheral tissues and body fluids and that treatment was well-tolerated at supraphysiological levels.
Steroids are administered in supraphysiological doses and usually in combination with other licit and illicit substances.
Supraphysiological estradiol hlevels do not affect oocyte and embryo quality in oocyte donation cycles.
The majority of studies carried out using animal models show that concurrent administration of Hg and Se in diverse chemical forms at supraphysiological concentrations reduces toxicity of Hg in the case of acute as well as chronic exposure.
Repeated supraphysiological stimulation of the dopaminergic system produced by the continuous use of opioids can induce changes in the plasticity of the brain (at the level of the glutamatergic system in the circuits linking the prefrontal cortex with the striatum), resulting in a decrease in the inhibitory control of seek and consume behavior, which can then become compulsive (Kalivas & Volkow, 2005) and which we know as addiction.
9- Low-dose aspirin: Supraphysiological ovarian stimulation may cause platelet hyperstimulation, which is associated with OHSS.
(7,8) The negative inotropic effect of supraphysiological adrenaline levels switches 2-adrenoceptor coupling in ventricular cardiomyocytes, resulting in stunning of the apical myocardium, a zone rich for -adrenoceptors.
Supraphysiological insulin concentrations may bridge the gap between age-related insulin resistances of the muscle protein synthesis.
The large (supraphysiological) supplementation consumption can cause both damage and health benefits, however, the used without proper guidance can increase the risk of intoxication (e.g.
Strain hardening of red blood cells by accumulated cyclic supraphysiological stress.