(10,11,12) The resulting serum profile provided by bid dosing from the metered-dose pump dispenser (Fig 1) is believed to provide a unique combination of advantages related to safety and efficacy, including: (i) no touch administration that avoids transference; (ii) fast/easy self-administration requiring only about 10 seconds per dose; (iii) very low risk of experiencing supraphysiological
T even at the maximum recommended daily dose due to a divided dose (13); and, (iv) retention of gonadotropin feedback with potential retention of sperm count and the possibility of lessening of testicular atrophy.
 At supraphysiological
ICS doses, 50% of children can be expected to develop HPAS,  while at physiological doses (i.e.
Chen's team reported data indicating AGU gene therapy resulted in dose-dependent, complete or near-complete elimination of toxic substrate in central and peripheral tissues and body fluids and that treatment was well-tolerated at supraphysiological
Steroids are administered in supraphysiological
doses and usually in combination with other licit and illicit substances.
estradiol hlevels do not affect oocyte and embryo quality in oocyte donation cycles.
The majority of studies carried out using animal models show that concurrent administration of Hg and Se in diverse chemical forms at supraphysiological
concentrations reduces toxicity of Hg in the case of acute as well as chronic exposure.
stimulation of the dopaminergic system produced by the continuous use of opioids can induce changes in the plasticity of the brain (at the level of the glutamatergic system in the circuits linking the prefrontal cortex with the striatum), resulting in a decrease in the inhibitory control of seek and consume behavior, which can then become compulsive (Kalivas & Volkow, 2005) and which we know as addiction.
9- Low-dose aspirin: Supraphysiological
ovarian stimulation may cause platelet hyperstimulation, which is associated with OHSS.
(7,8) The negative inotropic effect of supraphysiological
adrenaline levels switches 2-adrenoceptor coupling in ventricular cardiomyocytes, resulting in stunning of the apical myocardium, a zone rich for -adrenoceptors.
insulin concentrations may bridge the gap between age-related insulin resistances of the muscle protein synthesis.
The large (supraphysiological
) supplementation consumption can cause both damage and health benefits, however, the used without proper guidance can increase the risk of intoxication (e.g.
Strain hardening of red blood cells by accumulated cyclic supraphysiological