52] demonstrated that GCs at suprapharmacologic
concentration, in contrast to low-dose, showed massive lethal effect possibly by inducing apoptosis in human myeloid leukemic cells in vitro .
87) The clinical relevance of the rat data that led to the early termination of the above study is uncertain given the long duration of therapy (80-90% of the normal life span of the rats being tested) and the suprapharmacologic
dosages used (rats were treated for about 25-30 bone turnover cycles compared with 1-3 bone turnover cycles for postmenopausal women).
We postulated that since PPE is a pulmonary capillary injury, perhaps a preemptive, suprapharmacologic
dose of steroids might be beneficial.