doses of intravenous dexamethasone followed by cyclosporine in the treatment of toxic epidermal necrolysis," Indian Journal of Dermatology Venereology and Leprology, vol.
This mistake often leads to suprapharmacologic
recommendations and can potentially overdose patients by factors of 20-fold to 500-fold, depending on specific supplement and amounts prescribed.
 demonstrated that GCs at suprapharmacologic
concentration, in contrast to low-dose, showed massive lethal effect possibly by inducing apoptosis in human myeloid leukemic cells in vitro .
"We postulated that since PPE is a pulmonary capillary injury, perhaps a preemptive, suprapharmacologic
dose of steroids might be beneficial."
At this time, suprapharmacologic
dosing of folic acid has not reduced Hcy levels in ESRD patients.