suprapharmacologic

suprapharmacologic

 [soo″prah-fahr″mah-kah-loj´ik]
much greater than the usual therapeutic dose or pharmacologic concentration of a drug.

suprapharmacologic

/su·pra·phar·ma·co·log·ic/ (-fahr″mah-ko-loj´ik) much greater than the usual therapeutic dose or pharmacologic concentration of a drug.
References in periodicals archive ?
52] demonstrated that GCs at suprapharmacologic concentration, in contrast to low-dose, showed massive lethal effect possibly by inducing apoptosis in human myeloid leukemic cells in vitro [52].
87) The clinical relevance of the rat data that led to the early termination of the above study is uncertain given the long duration of therapy (80-90% of the normal life span of the rats being tested) and the suprapharmacologic dosages used (rats were treated for about 25-30 bone turnover cycles compared with 1-3 bone turnover cycles for postmenopausal women).
We postulated that since PPE is a pulmonary capillary injury, perhaps a preemptive, suprapharmacologic dose of steroids might be beneficial.