In acute appendicitis there are neutrophils in mucosa, wall of appendix and congested blood vessel with fibrinous exudates in the serosa while suppurative appendicitis associated with obstruction (fecalith, ball of worms) and abscess formation within the wall and foci of suppurative necrosis
in the mucosa.5
within granulomas was rarely reported.
It produces a leukocidal exotoxin that reduces the protective white blood cells from ingesting bacteria (phagocytosis) and causes suppurative necrosis
. However, the organism cannot penetrate intact healthy skin (Radostits et al., 2000).
(5) Luminal obstruction favours bacterial penetration submucosally, transmural suppurative necrosis
of the appendicular wall and gangrene and necrosis causing localised or generalised peritonitis.
Autopsy showed enlargement of lungs, liver, and spleen with many abscessed areas of suppurative necrosis
. An extensive bronchopneumonia was also shown.
The initial tissue reaction involves an intensely suppurative necrosis
and accumulation of polymorphonuclear leukocytes, followed by invasion of macrophages, epithelioid ceils, and lymphocytes as the suppurative lesions become granulomatous.