SOCS3

(redirected from suppressor of cytokine signalling 3)

SOCS3

A gene on chromosome 17q25.3 that encodes a protein which interacts with multiple activated proteins of the tyrosine kinase signalling pathway, including IGF1 receptor, insulin receptor and JAK2.

Molecular pathology
SOCS3 is thought to be a susceptibility gene for atopic dermatitis.
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A critical role for suppressor of cytokine signalling 3 in promoting Ml macrophage activation and function in vitro and in vivo.
Culig, "Suppressor of cytokine signalling 3 is up-regulated by androgen in prostate cancer cell lines and inhibits androgen-mediated proliferation and secretion," Endocrine-Related Cancer, vol.
Non-response to antiviral therapy is associated with obesity and increased hepatic expression of suppressor of cytokine signalling 3 (SOCS-3) in patients with chronic hepatitis C, viral genotype 1.