Suppressor of cytokine signalling 3 | definition of suppressor of cytokine signalling 3 by Medical dictionary
SOCS3 (redirected from suppressor of cytokine signalling 3)
SOCS3 A gene on chromosome 17q25.3 that encodes a protein which interacts with multiple activated proteins of the tyrosine kinase signalling pathway, including IGF1 receptor, insulin receptor and JAK2.
SOCS3 is thought to be a susceptibility gene for atopic dermatitis.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive
A critical role for suppressor of cytokine signalling 3
in promoting Ml macrophage activation and function in vitro and in vivo.
Culig, "Suppressor of cytokine signalling 3
is up-regulated by androgen in prostate cancer cell lines and inhibits androgen-mediated proliferation and secretion," Endocrine-Related Cancer, vol.
Non-response to antiviral therapy is associated with obesity and increased hepatic expression of suppressor of cytokine signalling 3
(SOCS-3) in patients with chronic hepatitis C, viral genotype 1.