suppressor gene


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Related to suppressor gene: lethal gene, suppressor mutation

suppressor gene

[səpres′ər]
a gene that is able to reverse the effect of a specific kind of mutation in other genes.

suppressor gene

A GENE capable of suppressing the expression of a mutant gene at a different locus.
References in periodicals archive ?
Insensitivity to growth inhibitory signals--tumour suppressor genes
Tumor suppressor genes or anti-oncogenes are lost due to chromosomal alterations during tumor formation.
Mutations of tumor suppressor gene P53 (TP53) in tumor tissue and cellular urine sediments in urinary bladder cancer.
Another gene, referred to as SMAD4, also found in the region affected by 18q LOH, bas been suggested as the critical putative tumor suppressor gene in colorectal carcinomas.
In particular Introgen has found that when cancer cells are pretreated with chemotherapy agents designed to cause DNA damage, followed by administration of a vector encoding a tumor suppressor gene, such as ADVEXIN or INGN 241, the result is an increase in expression of the selected tumor suppressor gene.
The p53(+/-) mouse has one functional wild-type allele and one inactivated allele of the tumor suppressor gene p53.
Mount Sinai School of Medicine (New York, NY) has patented a novel tumor suppressor gene, SSeCKS.
More specifically, hypermethylation of the p15 tumor suppressor gene has been found in the majority of patients with advanced MDS, and in nearly all of the patients with AML arising from MDS.
3 Tumor Suppressor Gene Consortium, a team of researchers from M.
One broad example is the center's continuing work on the association between lung cancer and the p53 tumor suppressor gene.
The patent relates to treatment methods employing the mda-7 tumor suppressor gene.
PTEN is a tumor suppressor gene, helping to direct the growth and division of cells.