suppressor gene


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Related to suppressor gene: lethal gene, suppressor mutation

suppressor gene

A GENE capable of suppressing the expression of a mutant gene at a different locus.
References in periodicals archive ?
The study aimed to develop a novel therapeutic approach for the treatment of cancer using a combination of the tumor suppressor gene TUSC2 and immunotherapy, including immune checkpoint inhibitors and anti-PD1 and/or anti-CTLA-4 antibodies.
[USA], Sep 22 ( ANI ): Turns out, mutations in the tumor suppressor gene SPOP contribute to cancer by disrupting a process called liquid-liquid phase separation.
Hence, MBD1 might be a tumor suppressor gene in advanced CRC.
Mutations in the p53 Tumor Suppressor Gene. Genes Cancer.
Major finding: The high-risk tumors showed greater induction of biologic pathways related to cancer signaling, fibrosis, and extracellular matrix remodeling, and inhibition of the tp53 tumor suppressor gene.
The transcription factor Rb, a known tumor suppressor gene, reduced expression in a small percentage of oral tumours.
CU-Boulder Professor Min Han said the research team was interested in how a common tumor suppressor gene known as Retinoblastoma 1, or Rb, behaved under conditions of starvation.
Quantitative methylation profiles for multiple tumor suppressor gene promoters in salivary gland tumors.
They evaluated Wtl (Wilms' tumor suppressor gene) mRNA splice variant ratios and reduced mRNAs of the Wtl transcriprional targets Sdcl (syndecan-1), Pax2 (paired box gene 2), Egfr (epidermal growth factor receptor), and retinoic acid receptor, alpha (Rar [alpha]).
Four years ago, we started to profile molecular markers genes for cancer patients and at the beginning with the oncogene tumor suppressor gene P53, whose critical role is evident by the fact that it is mutated in approximately 50% to 70% of all human cancer.
Perth, Australia, July 25, 2011 - (ABN Newswire) - BPH Energy Limited (ASX:BPH) investee company Molecular Discovery Systems (MDS) is pleased to confirm the publication of a peer reviewed scientific paper supporting the role of the cancer tumour suppressor gene, HLS5 (also known as TRIM35).