suppressor gene


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Related to suppressor gene: lethal gene, suppressor mutation

suppressor gene

[səpres′ər]
a gene that is able to reverse the effect of a specific kind of mutation in other genes.

suppressor gene

A GENE capable of suppressing the expression of a mutant gene at a different locus.
References in periodicals archive ?
After ruling out the BRCA2 gene, we found that FRY, a gene immediately adjacent to the rat BRCA2 suppressor gene, was mutated in the susceptible F344 strain," said Dr.
Next we'll examine whether the tumor suppressor gene is involved in other induced melanoma models that we've been studying," Nairn says.
MGI and MethylGene intend to further evaluate MG98 in cancers where silencing of tumor suppressor genes by DNA methyltransferase has been documented.
Cross-sectional surveys restricted to patients with cancer have revealed that aberrant methylation of several tumor suppressor genes is associated with smoking.
They also made a number of important findings in the cancer research field; isolation of the APC gene (a tumor suppressor gene for colorectal cancer) as well as p53-target genes including p53R2 (a key enzyme for repairing damaged-DNA) and BAI1 (an angiogenesis inhibitor).
They also made a number of important findings in the cancer research field; isolation of the APC gene (a tumour suppressor gene for colorectal cancer) as well as p53-target genes including p53R2 (a key enzyme for repairing damaged-DNA) and BAI1 (an angiogenesis inhibitor).
The process that inactivates a tumour suppressor gene often involves deletion of both copies of the gene in the cancer (one copy originally inherited from the mother and one from the father).
We are pleased to add Affymetrix, a leader in DNA array technology, as a licensee of our diagnostic and research rights to this important tumor suppressor gene, and we will continue to license our remaining intellectual property in this area.
To further assess whether Rak is a bona fide breast tumor suppressor gene, we sought to determine if loss of Rak expression would transform normal mammary epithelial cells," Lin said.
Aging Pathway Associated with Important Human Tumor Suppressor Gene -
China set a new milestone in the history of gene therapy with its approval of Gendicine, a recombinant adenovirus encoding human p53 tumor suppressor gene, for the treatment of head and neck squamous cell carcinoma, and Gendicine is now the core of the country's active clinical gene therapy program, according to a report in the September 2005 issue (Volume 16, Number 9) of Human Gene Therapy, a peer-reviewed journal published by Mary Ann Liebert, Inc.
Washington, January 21 (ANI): A study conducted by Mayo Clinic researchers has shown that an experimental drug can turn on a powerful tumour suppressor gene to halt the growth of cancer cells.