suppressor cells


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sup·pres·sor cells

cells of the immune system that inhibit or help to terminate an immune response, for example, suppressor macrophages and suppressor T cells.

suppressor cells

see T lymphocyte.
References in periodicals archive ?
Gabrilovich, "Subsets of myeloid-derived suppressor cells in tumor-bearing mice," Journal of Immunology, vol.
Therapeutic targeting of myeloid-derived suppressor cells," Current Opinion in Pharmacology, vol.
Serafini R Borrello I, Bronte V Myeloid suppressor cells in cancer: recruitment, phenotype, properties, and mechanisms of immune suppression.
The Hopkins team also analyzed gene expression patterns of the myeloid-derived suppressor cells and found that sildenafil blocked two genes regulating enzymes -- arginase and nitric oxide synthase -- which are key to triggering immune suppression via MDSCs.
Targeting the heightened COPD-induced immune response in the lungs, CBD/THC medications mobilize myeloid-derived suppressor cells (MDSCs), a group of white blood cells that inhibit T-cell proliferation and activation.
The investigators also found that treating mice with topical catalase inhibited the migration of the suppressor cells into UVB-exposed skin, suggesting that the influx of these cells in males might be due to the relatively lower skin-catalase activity.
Generex Biotechnology Corporation (Toronto, Canada), announced today the award of Japan patent 3534761 to its Antigen Express affiliate for certain Ii-Key immunologically active compounds and their use in modifying immune responses to antigenic eptitopes recognized by T helper and T suppressor cells.
Together with earlier work by these investigators showing that NOV-002 administered to mice suppressed the function of T cell-inhibiting myeloid-derived suppressor cells, these findings provide further evidence of the ability of NOV-002 to increase anti-tumor cellular immune responses in vivo.
CXCR4 is a chemokine receptor that modulates immune function and angiogenesis through the trafficking of key immune cells such as T- cells, dendritic cells, and myeloid derived suppressor cells.
Effi-DEM is a new-generation checkpoint inhibitor that inhibits the Signal Regulatory Protein-a (SIRP-alpha) receptor expressed by myeloid suppressor cells and tumour-associated macrophages.
Effi-DEM is a new-generation checkpoint inhibitor that blocks the Signal Regulatory Protein-a (SIRP-alpha) receptor expressed by myeloid suppressor cells (MDSC) and tumor-associated macrophages (TAM).
Further, the scientists found that what's keeping the natural killers from doing their job are other cells called myeloid-derived suppressor cells.