suppressor cells


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sup·pres·sor cells

cells of the immune system that inhibit or help to terminate an immune response, for example, suppressor macrophages and suppressor T cells.

suppressor cells

see T lymphocyte.
References in periodicals archive ?
is a drug development company focused on discovery, development, and commercialization of suppressor cell modulators (SCM), a new class of small molecule cancer immunotherapies which enable the immune system to attack cancer by regulating myeloid-derived suppressor cells.
which has developed a first-in-class suppressor cell modulator cancer immunotherapy, today announced it has completed a $4 million Series A financing, including fifteen new shareholders.
Boosting suppressor cells could prevent or help counter infection, they suggest.
When they added the suppressor cells back to the culture, signs of the virus disappeared.
Our LRI funds allowed us to carry out the early experiments that led to the definition of the CD8 suppressor cells.
For years, researchers have known that a diverse group of white blood cells called myeloid-derived suppressor cells (MDSC) are more abundant in cancer patients than in healthy individuals.
The mechanism underlying these results, the authors note, is believed to be entinostat's inhibition of myeloid derived suppressor cells (MDSCs) at concentrations which importantly have only modest effects on CD8+ T cells creating the potential for a large therapeutic window in which MDSCs can be depleted while sparing CD8+ T cells.
These new results, which are consistent with earlier data demonstrating entinostat inhibition of regulatory T cells, show that epigenetic therapy with entinostat may increase immunogenicity of tumors and reduce resistance to immune therapy through potent inhibition of host immune suppressor cells.
of University of Pittsburgh Medical Center, received the Ostrow Graff Family Discovery Grant to study an immune cell called myeloidCEderived suppressor cells, which have not been extensively studied in psoriasis.
Differential sensitivity of T suppressor cell expression to inhibition by histamine type 2 receptor antagonists.