suppressor cells


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sup·pres·sor cells

cells of the immune system that inhibit or help to terminate an immune response, for example, suppressor macrophages and suppressor T cells.
References in periodicals archive ?
Cheng et al., "Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells," The Journal of Immunology, vol.
Mantovani, "The growing diversity and spectrum of action of myeloid-derived suppressor cells," European Journal of Immunology, vol.
Immune suppression by neutrophils and granulocytic myeloid-derived suppressor cells: similarities and differences.
Wright, "Myelopoiesis-associated immune suppressor cells in mice bearing metastatic Lewis lung carcinoma tumors: y interferon plus tumor necrosis factor a synergistically reduces immune suppressor and tumor growth-promoting activities of bone marrow cells and diminishes tumor recurrence and metastasis," Cancer Research, vol.
Ostrand-Rosenberg, "Reduction of myeloid-derived suppressor cells and induction of M1 macrophages facilitate the rejection of established metastatic disease," The Journal of Immunology, vol.
Myeloid-derived suppressor cells (MDSC) is a well-known immune suppression factor that consists of immature myeloid cells including the precursors of DCs.
Horn et al., "HMGB1 enhances immune suppression by facilitating the differentiation and suppressive activity of myeloid-derived suppressor cells," Cancer Research, vol.
The second group of mice had tumors and were injected with myeloid derived suppressor cells and treated with the antihistamine, cimetidine.
Tumor tissues contain myeloid-derived suppressor cells (MDSCs), which can suppress adaptive immunity.
As for the bigger questions, such ashow the dody actually distinguishes between "self' and "nonself' and why certain people develop autoimmunity, Gleicher says, "If I knew that I'd win the Nobel Prize in medicine.' However, he notes, autoantibody levels are normally regulated by specialized suppressor cells, and "suppressor activity in the female is set at a higher thermostat level than in the male,' leaving even healthy women with relatively high levels of autoantibodies.
A subset of myeloid derived suppressor cells (CD38+ MDSCs), CD38+ regulatory T cells (Tregs) and CD38+ B cells (Bregs) were decreased by daratumumab.4 Daratumumab is being evaluated in a comprehensive clinical development programme across a range of treatment settings in multiple myeloma, such as in frontline and relapsed settings.
When aggregated with the cohorts previously reported, the data shows a 50% objective response rate in advanced melanoma with GR-MD-02 in combination with Keytruda, and a significant decrease in the frequency of suppressive myeloid-derived suppressor cells, or MDSC, following treatment in the responding patients was observed.