Chen et al., "Recommendations for myeloid-derived suppressor cell
nomenclature and characterization standards," Nature Communications, vol.
Myeloid-derived suppressor cells
(MDSCs) are another population of immunosuppressive cells.
In addition to functions in modulating immune cells, these tumor-associated immune-suppressive cells, which mainly include tumor-associated macrophages, myeloid-derived suppressor cells
(MDSCs), T-regulatory (Treg) cells, and NK cells, have been widely demonstrated to support CSCs through multiple pathways.
In MM, recent evidence attributes a major role in immunosuppression to myeloid-derived suppressor cells
(44) [beta]2-adrenergic agonists restore defective [CD8.sup.+] T suppressor cell
function in SPMS.
Anjos et al., "Functional myeloid-derived suppressor cell
subsets recover rapidly after allogeneic hematopoietic stem/progenitor cell transplantation," Biology of Blood and Marrow Transplantation, vol.
Gabrilovich, "Molecular mechanisms regulating myeloid-derived suppressor cell
differentiation and function," Trends in Immunology, vol.
Ireland et al., "Myeloid-derived suppressor cell
accumulation and function in patients with newly diagnosed glioblastoma," Neuro-Oncology, vol.
Differential sensitivity of T suppressor cell
expression to inhibition by histamine type 2 receptor antagonists.
Since Tregs are notorious for dampening the effectiveness of tumor-directed immunity in cancer patients, the study's finding may pave the way for a new and promising strategy to unleash the patient's immune response from the stifling grip of suppressor cell
Michaud et al., "CCL2 promotes colorectal carcinogenesis by enhancing polymorphonuclear myeloid-derived suppressor cell
population and function," Cell Reports, vol.
But surgery causes another kind of immune cell, called a myeloid-derived suppressor cell
(MDSC), to block the NK cells.