suppression test

suppression test

A test or assay–eg, dexamethasone suppression test, used to determine whether a substance–hormone or protein being produced in excess is under the control of regulating or releasing factor(s), and therefore responsive to a feedback loop, or whether the excess production is autonomous, and not under feedback control. Cf Stimulation test.
References in periodicals archive ?
VOR function can be assessed by various methods including a measure of dynamic visual acuity (DVA), and by performing the Halmagyi-Curthoys test, the head shaking test for nystagmus and the VOR suppression test.
The most common screening tests for suspected Cushing syndrome are the low-dose dexamethasone suppression test and a 24-h urinary free cortisol (7).
Lacroix and colleagues reported that subclinical AIMAH patients usually present with slightly elevated midnight plasma or salivary cortisol, subnormal suppression following 1 mg overnight dexamethasone suppression test, a partially suppressed ACTH, normal 24-hour urinary free cortisol production and absence of clinical signs of CS, paralleled by non-specific syndromes, such as hypertension and diabetes.
There are three screening tests for endogenous Cushing's syndrome that all primary care physicians ought to be familiar with: the 24-hour urine cortisol test, the bedtime salivary cortisol test, and the overnight 1-mg dexamethasone suppression test.
3] suppression test, 50 [micro]g, 100 [micro]g and 200 [micro]g of [T.
Stress was assessed from both a biological perspective, by assessing HPA axis function with a weight-adjusted very-low-dose dexamethasone suppression test (DST), and a psychological perspective, with self-report questionnaires.
The high-dose dexamethasone suppression test can be combined with the corticotropin-releasing hormone stimulation test for the diagnosis of EAS with a sensitivity of 100% and specificity of 98% (6, 7).
5 ng/mL VMA: vanilylmandelic acid, DST: dexamethasone suppression test, DHEA-S: dehydroepiandrosterone sulfate, 17-OHP: 17-hydroxypogestrone.
A combination of different tests, such as the different versions of the high dose dexamethasone suppression test (in EAS cortisol should not be suppressed) and the peripheral CRF stimulation test (where injectable CRF is available) (CD patients should have a plasma ACTH response to CRF) may help the differential diagnosis between CD and EAS (13).
Currently, diagnosis of a pseudo-Cushing state is normally based on negative tests for Cushing's, including a dexamethasone-CRH (corticotropin-releasing hormone) stimulation test, a loperamide suppression test, and/or a 1-mg overnight dexamethasone-suppression test, and/or resolution of hypercortisolism over the course of up to 18 months' follow-up.
There is evidence to suggest that subclinical hypercortisolism, defined as having two of three abnormalities in HPA axis function (increased 24-hour urine free cortisol, failure of the dexamethasone suppression test, and decreased levels of ACTH), may contribute to the development of type 2 diabetes, Dr.
Generally, we consider the overnight dexamethasone suppression test to be the gold standard test," said Schott.