The supporting cells
were observed on the surface of the lamellae in the middle and posterior regions (Fig.
Of the remaining surface epithelial cells, the immunoreactive cells are sensory cells, which are widely scattered among the supporting cells
When the researchers performed the same experiment with cells taken from 2-week-old mice, they found that only about 2 percent of the supporting cells
FGF9 seemed to 'awaken' the supporting cells
and stimulated their wrapping around the otherwise fragile blood vessel wall," said Canadian researcher Matthew Frontini, from the University of Western Ontario.
After determining that inner ear supporting cells
supply NT3, the team turned to a technique called conditional gene recombination to see what would happen if they boosted NT3 production by the supporting cells
Within the collaboration, Kadimastem will screen compounds in proprietary assays based on these myelin-producing cells and differentiated nerve supporting cells
, with the aim of identifying compounds with potential efficacy in MS, and potential effect in other neurodegenerative diseases.
In the latest work, investigators found that blocking the Notch pathway increases the formation of new hair cells not from remaining hair cells but from certain nearby supporting cells
that express a protein called Lgr5.
Kadimastem is also equipped to generate stem cell-derived astrocytes, the neural supporting cells
shown to be involved in neurodegenerative diseases.
These supporting cells
turned into new hair cells upon treatment with the drug.
The research team found that by activating the supporting cells
, new blood vessel sprouts in adult mice did not shrivel up and disappear but instead lasted for over a year.
Surrounding each hair cell are four supporting cells
, which recycle the ions that hair cells use to send their electrical messages.