n a condition in which structures innervated by a dysfunctional peripheral nerve be-have abnormally, with tightening of muscles and development of trigger points.
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1) Although exposure to dopamine D2 antagonism results in postsynaptic receptor upregulation and supersensitivity that underlies the development of dyskinesia, this process is often rapidly reversible in animal models.
Probable mechanism suggested by authors is dopamine supersensitivity.
It has new coverage of desensitization and supersensitivity, competitive and noncompetitive antagonism, and polypharmacy and adverse reactions; a revised chapter on cannabis to include new street drugs, the herbal marijuana alternatives; updated coverage of child and adolescent psychopharmacology and the treatment of depression in the elderly and Parkinson's disease; a revised chapter on challenging times for mental health, to include new policy developments and the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders; and a new feature detailing facts or news related to chapter material.
Supersensitivity psychosis, which is frequently observed together with TD and is considered to have a similar etiology as TD, is a psychotic relapse phenomenon that occurs after the withdrawal of an antipsychotic drug or rapid reduction of the drug dosage (4).
In the United States 24% of our population is born with a supersensitivity to statins.
The main central mechanisms include (a) the progression of nigrostriatal degeneration, which results in the reduction of the capacity of storing dopamine in the presynaptic vesicles and releasing them physiologically, (b) enhanced conversion of levodopa to dopamine and aberrant release in the striatum as false neurotransmitter by serotoninergic neurons, (c) alterations in dopaminergic receptors that undergo plastic changes, which include supersensitivity to dopamine because of the loss of nigrostriatal projections, desensitization, and downregulation because of the presence of nonphysiological high doses of dopamine, and (d) increased glutamatergic activity in the striatum [87,88].
However, the Johansen-Juselius test procedure is also not immune to supersensitivity to the selection of lag-lengths.
Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors.
Migraine is most similar to pure autonomic failure in terms of reduced supine plasma norepinephrine levels, peripheral adrenergic receptor supersensitivity, and clinical symptomatology directly related to sympathetic nervous system dysfunction.
HET] mice have reduced ACh transmission by central cholinergic neurons (22), compensatory mechanisms, such as supersensitivity of cholinergic receptors, could account for the normal sleep-wake physiology.
This may reflect heightened sensitivity to the effects of serotonergic dysregulation, and suggests that what underlies impulsive aggression is either supersensitivity to serotonergic disturbances or susceptibility to fluctuations in central serotonergic availability.