superoxide dismutase


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su·per·ox·ide dis·mu·tase (SOD),

an enzyme that catalyzes the dismutation reaction, 2O2·- + 2H+ → H2O2 + O2; there are three isozymes of SOD: an extracellular form (ECSOD) that contains copper and zinc, a cytoplasmic form that also contains copper and zinc, and a mitochondrial form that contains manganese; a deficiency of SOD is associated with amyotrophic lateral sclerosis.

superoxide dismutase (SOD)

an enzyme composed of metal-containing proteins that converts superoxide radicals into less toxic agents. It is the main enzymatic mechanism for clearing superoxide radicals from the body.

superoxide dismutase

Chemistry
An enzyme present in all aerobic organisms which catalyses the reaction O2•– + O2•–  + 2H+ = H2O2 + O2. Superoxide dismutase serves to protect the organism against the havoc caused by oxygen free radicals.

Fringe medicine
Concentrates of superoxide dismutase have been marketed for their claimed ability to reduce ageing and degeneration of tissue, and as a therapy for cataracts, arthritis and other age-related phenomena.

su·per·ox·ide dis·mu·tase

(sū'pĕr-oks'īd dis'myū-tās)
An enzyme that catalyzes the dismutation reaction 2O2·- + 2H+→ H2O2 + O2; a deficiency is associated with amyotrophic lateral sclerosis.

superoxide dismutase

A natural body enzyme that converts the superoxide free radical to hydrogen peroxide, which is then catalyzed to water. The gene for superoxide dismutase is on the long arm of chromosome 21 near the Alzheimer's locus. Brain tissue is highly susceptible to free radical damage. People with Alzheimer's disease have reduced levels of superoxide dismutase.

superoxide dismutase (sōō·per·ôkˑ·sīd dis·myōōˑ·tās),

n an enzyme that comprises metalloproteins and clears the body of superoxide radicals by converting them into less toxic substances.

superoxide

any compound containing the highly reactive superoxide ion O2, a common intermediate in numerous biological oxidations and an important killing mechanism generated in lysosomes of phagocytes after they have phagocytosed microorganisms.

superoxide dismutase
an enzyme that converts peroxides to two kinds of molecules in different states of oxidation. Present in aerobic bacteria.
References in periodicals archive ?
Effects of magnetic field on activity of superoxide dismutase and catalase in Glycine max (L.
Escherichia coli expresses a copper-and zinc-containing superoxide dismutase.
The protective effects of atlopurinol and superoxide dismutase on noise-induced cochicar damage.
The deleterious effect of the free radicals is usually prevented by a series of mechanisms including enzymatic defenses such as superoxide dismutase (SOD) and by non-enzymatic quenching autoxidant such as glutathione (Freeman & Crapo 1982).
In contrast, ozone exposure caused a decline in the levels of two chloroplastic antioxidant mRNAs (iron superoxide dismutase and glutathione reductase) and two photosynthetic protein mRNAs (chlorophyll a/b binding protein and ribulose 1,5 biphosphate carboxylase/oxygenase small subunit).
SOD: Superoxide dismutase, POD: Peroxidase, CAT: Catalase, GR: Glutathione reductase, ROS: Reactive oxygen species, [S.
In diabetic wound tissues, the protein level of manganese superoxide dismutase (MnSOD) was unchanged whereas MnSOD activity was inhibited and its nitration was potentiated; Gl-PS administration suppressed MnSOD nitration and increased MnSOD and glutathione peroxidase (GPx) activities.
Researchers at Washington State University also explored the activities of these enzymes after subjects drank one of two different cranberry beverages or a placebo, Subjects consuming either cranberry beverage had significantly increased levels of the important antioxidant enzyme superoxide dismutase (SOD) compared with placebo.
Since superoxide is generally removed from the cell with the help of a detoxifying enzyme called manganese superoxide dismutase (MnSOD), Gius hypothesized that the Sirt3 deficiency may abnormally regulate MnSOD.
The assets consisted of 1) Rifalazil, a Phase II antibiotic, 2) a library of novel rifamycin compounds, and 3) a clinical stage superoxide dismutase mimetic (SODm) and a library of SODm small molecules.
One such mechanism may involve superoxide dismutase (SOD), which detoxifies reactive superoxide radicals produced by activated macrophages.
Nine contributions and concluding remarks by editor Prasher (a psychiatrist affiliated with South Birmingham Primary Care Trust and King's College London) discuss topics including amyloid beta and tau proteins, superoxide dismutase, macrocytosis as a peripheral marker, thyroid disorders, neurophysiological changes associated with dementia, and neuroimaging studies of individuals with Down syndrome.