superiority trial


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superiority trial

A clinical trial designed to prove that the response to the investigational product is superior to a comparable active agent or placebo control.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

superiority trial

A study that directly compares two treatments to see which of them achieves better results.
See also: trial
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Although the hypotheses in (1) are very natural and intuitive for the superiority trial, there are many discussions about the establishment of superiority from regulatory agencies, see for example Dunnet and Gent [3], Lesafre [7], Sacket [8], and Sacket.
When the aim of the study is to show that an experimental (E) treatment is superior to a control (C) treatment, the RCT is called a superiority trial and the associated statistical test is a superiority test.
Panelists recommended that effectiveness should be shown in a placebo-controlled superiority trial; several panelists thought the drug had potential as a second-line treatment for ABS and also recommended studying gemifloxacin for ABS treatment failures.
The study was a U.S.-based, randomized, double-masked, superiority trial that enrolled 64 subjects, in whom both eyes were treated on separate days with Eyenovia's proprietary MicroStat fixed combination formulation of phenylephrine and tropicamide.
Sonia Johnson, D.M., from University College London, and colleagues conducted a randomized controlled superiority trial with participants recruited from six crisis resolution teams.
According to the company, the FDA approval is reportedly based upon data from the landmark PLATO (A Study of PLATelet Inhibition and Patient Outcomes) study, a superiority trial that compared treatment with BRILINTA to clopidogrel in 18,624 ACS patients worldwide.
Superiority trial designs allow for demonstration of patient and payor benefits over standard-of-care drugs.