supercoil

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supercoil

(so͞o′pər-koil′)
n.
A structure of a helix, especially a DNA molecule, in which the axis of the helix itself is coiled, causing the helix to loop over itself.
intr.v. super·coiled, super·coiling, super·coils
To form a supercoil.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
References in periodicals archive ?
Type II DNA topoisomerases, through DSB induction and repair, act to resolve such obstacles using a repertoire of supercoil introduction/relaxation, catenation/decatenation, and knotting/unknotting processes [197, 198].
During semiconservative replication, the replisomal machinery at the advancing replication fork forces the intertwined DNA strands ahead of it to become overwound or positively supercoiled. These positive super-coils are redistributed behind the fork by the rotation of the replicative machinery around the helical axis of the parental duplex.
To understand more completely how DNA supercoils and the forces that make the strands writhe, Tamar Schlick, a mathematician and Howard Hughes Medical Institute researcher at New York University, and her colleagues have developed a computer model that links knot theory to biochemistry
Addressing a meeting of the Society of Industrial and Applied Mathematics in San Diego last week, Schlick explained that her computer simulations reveal the influence of salt concentrations on the tightness of DNA's supercoils.
The Supercoil uses spacers of lead wire encapsulated with Teflon and polyvinylidene chloride tubes to flatten and separate the individual layers of Teflon tubing.
This compound displays potent antitumor efficacy by targeting topoisomerase I, an enzyme involved in the relaxation of DNA supercoils [101].
The protein structure, called the histone octamer, organizes DNA into supercoils to keep genes compact and untangled.
They suggest that the degree to which these DNA supercoils tighten and loosen influences which genes are active in a cell.
The iconic image of DNA as a rigid twisted ladder is reimagined as one of dynamic looping strands in supercoiled form.
(Answer: Intact plasmids are circular and "supercoiled," meaning that the double strands of the plasmid twist around each other.
(Answer: There are a) supercoiled forms of the plasmids, which are the normal forms in bacteria, as well as b) linear forms that result from breaks in both strands of DNA that are inadvertently introduced during plasmid preparation, and c) "relaxed" circular forms [like an untwisted rubber band] that result from a break in only one strand of DNA during the isolation procedure.)
Supercoiled: "Supercoiling" is an abstract mathematical property, and represents the sum of what are termed "twist" and "writhe".