It also enables the biocatalyst and product/substrate to be segregated, with the possibility of controlling the biocatalyst microenvironment leading to enhanced activity ("superactivity
") whilst also stabilizing the enzyme.
is conditioned only by presence of the Ga in the solid solution.
To mimic urine of patients with PRPPS superactivity
, urines were enriched with hypoxanthine (100-120 mmol/mol creatinine), uric acid (>1900 mmol/mol creatinine), and xanthine (100-120 mmol/mol creatinine) (10).
In addition, no sample was available from patients with phosphoribosyl pyrophosphate synthase superactivity
. Because hypoxanthine in urine is characteristically increased in this disease, we expect no difficulties in diagnosing this defect with [sup.1]H-NMR spectroscopy.