Consider a different formulation of sumatriptan
or switch these patients to an alternative migraine medicine.
Group A patients were given sumatriptan
15 mgs and Group B patents received ergotamine 1 mg tablets maximum 6 tablets.
Nor was the powder associated with the "foul" taste patients often complain of when they use a liquid sumatriptan
nasal spray, he added.
Individuals were randomly given either 1 ginger capsule of 250 mg or 50 mg of sumatriptan
upon onset of headache.
9 in the sumatriptan
and ginger treated groups respectively.
After randomization of the patients into two groups, the first group was injected with 6 mg of Sumatriptan
subcutaneously plus 200 cc of normal saline in 20 minutes and the second group received 400 mg of sodium valproate (Depakine, SANOFI AVENTIS, France) in 200 cc of normal saline (in 20 minutes) plus 2 cc of subcutaneous normal saline.
Considering the extent of use of sumatriptan
in patients with migraine, the incidence of these events is extremely low.
But a 100mg dose of sumatriptan
was slightly better at delivering a pain-free response within two hours.
These occurred more commonly when taking aspirin than when taking a placebo, and more commonly when taking 100 mg sumatriptan
than when taking aspirin plus metoclopramide.
PHILADELPHIA -- Sumatriptan
and naratriptan do not appear to significantly raise the risk of major congenital malformations in fetuses that are exposed to the drugs in utero, according to the latest analysis of an international pregnancy registry.
The malformations that occurred in infants who were exposed to sumatriptan
in the first trimester included abnormal head circumference, single palmar crease and systolic murmur; moderate craniosynostosis; cerebral abnormality with developmental delay; partial cleft lip; ventricular septal defects (4); biliary atresia; diaphragmatic hernia; pyloric stenosis (3); anterior displacement of anus; hip dysplasia; Polydactyly; malformation of left hand; and Down syndrome (3).
The tablets - whose scientific name is Sumatriptan
Succinate - will be sold in 25mg, 50mg, and 100mg amounts to begin shipping immediately, Mylan said in a press release today just ahead of the stock market's regular trading close.