today announced that COMPASS, its Phase IIIb, cross-over clinical trial comparing the efficacy and safety of AVP-825 22mg to sumatriptan
100mg tablets for the treatment of acute migraine across multiple attacks, has been published and is available in hard copy at the 57[sup.
Individuals were randomly given either 1 ginger capsule of 250 mg or 50 mg of sumatriptan
upon onset of headache.
9 in the sumatriptan
and ginger treated groups respectively.
A burst of air delivers sumatriptan
just under the skin in less than a second.
Considering the extent of use of sumatriptan
in patients with migraine, the incidence of these events is extremely low.
These occurred more commonly when taking aspirin than when taking a placebo, and more commonly when taking 100 mg sumatriptan
than when taking aspirin plus metoclopramide.
But a 100mg dose of sumatriptan
was slightly better at delivering a pain-free response within two hours.
So far, the registry has amassed information on 761 pregnancies exposed to sumatriptan
and 88 exposed to naratriptan.
The pregnancy registry did not contain any data on the exposure to the combination of sumatriptan
Over the 12 months ending June 30, Sumatriptan
Succinate tablets had sales of $934 million, according to IMS Health.
The confidential terms of the settlement, which remain subject to government review, permit Par to sell generic versions of certain sumatriptan
injection products with an expected launch date during GSK's sumatriptan
pediatric exclusivity period which begins on August 6, 2008, but with the launch occurring not later than November 2008.
Today, there are seven triptans, including sumatriptan
(Imitrex), zolmitriptan (Zomig) and eletriptan (Relpax).