Horan et al., "Genetic polymorphisms in platelet-related proteins and coronary artery disease: investigation of candidate genes, including Nacetylgalactosaminyltransferase 4 (GALNT4) and sulphotransferase
1A1/2 (SULT1A1/2)," Journal of Thrombosis and Thrombolysis, vol.
After oral administration, besides oxidative metabolism, EE undergoes glucuronidation and sulphatation by specific enzymes (e.g., glucuronyltransferase and sulphotransferase
Crystal structure of estrogen sulphotransferase
. Nat Struct Mol Biol 4:904-908.
Genes that have been implicated in Larsen syndrome include filamin B , whichisinvolvedinthe cytoskeletal architecture, and carbohydrate sulphotransferase
3, which has also been implicated in other skeletal dysplasias .
Tibolone is also a sulphatase inhibitor, blocking conversion of oestrone sulphate to oestrone, as well as stimulating local sulphotransferase
It was observed in vitro that Hg exposure significantly altered the androgen synthesis pathway by inhibiting hydroxysteroid sulphotransferase
(HST) activity, thus reducing the conversion of dehydroepiandrosterone (DHEA) to dehydroepiandrosterone-sulphate (DHEAS) (21-24).
Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase
In addition, in vitro studies showed that Hg exposure significantly inhibited hydroxysteroid sulphotransferase
(HST) activity, thus reducing the conversion of dehydroepiandrosterone (DHEA) to dehydroepiandrosterone-sulphate (DHEA-S) (130, 131).
DHEA is metabolized to form DHEAS, and both hormones are metabolically interconvertible by the action of the enzymes sulphotransferase
for conjugation and sulphatase for hydrolysis, present in many tissues (Baulieu, 1996).
Sulpho-conjugation of ethanol in humans in vivo and by individual sulphotransferase
forms in vitro.
Glatt, "Toxicity studies with 5-hydroxymethylfurfural and its metabolite 5-sulphooxymethylfurfural in wild-type mice and transgenic mice expressing human sulphotransferases
1A1 and 1A2," Archives of Toxicology, vol.
The results confirmed that silymarin's phenolic compounds undergo extensive metabolism, as do almost all flavonoids, forming sulphate and glucuronide conjugates through the action of UDP-glucuronosyltransferases (UGTs) and sulphotransferases
(SULTs) in the small intestine and liver.