sulphoraphane


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sulphoraphane

An isothiocyanate phytochemical present—after conversion from glucoraphanin by myroinase—in cruciferous vegetables (e.g., Brussels sprouts, broccoli, cabbage), which has anticarcinogenic, antimicrobial and antidiabetic activity in experimental systems. 
It stimulates the production of phase-2 enzymes that play a role in detoxifying carcinogens; in rats, sulphoraphane reduces the incidence of mammary tumours induced by dimethylbenzanthracene (DMBA).

sulforaphane

, sulphoraphane (sŭl-fŏr′ă-fān″) [″ + Gr. phainein, to show],

SF

A sulfur-containing compound found in vegetables of the mustard family (Cruciferae). Like other isothiocyanates, it has been shown to prevent cancer in animals.
References in periodicals archive ?
Evidence indicates that sulphoraphane has beneficial effects such as reducing chronic inflammation, stopping uncontrolled cell division associated with early-stage cancer, and boosting the body's antioxidants.
In the presence of sulphoraphane, the NRF2 pathway was boosted and the macrophages' ability to engulf bacteria was restored.
Researchers who carried out a series of experiments on human prostate tissue and mice found that in cells with normally functioning PTEN, sulphoraphane had no effect on cancer development.
Researchers experimenting on human prostate tissue and mice found that, in cells with normally functioning PTEN, sulphoraphane had no effect on cancer development.
UCLA researchers report that sulphoraphane, a chemical found in broccoli and other cruciferous vegetables, can switch on a set of antioxidant genes and enzymes in specific immune cells, which then combat the injurious effects of free radicals.
Tests on mice genetically engineered to have the same condition showed they improved significantly after treatment with the plant chemical sulphoraphane.
A cancer-fighting compound found in the veg, sulphoraphane, reduced blistering associated with the condition in genetically engineered mice.
The variety has higher levels of sulphoraphane and will help the half of the human population which lacks a gene that allows the body to retain the protective plant chemical.
They include antioxidants, beta carotene, lutein, lycopene, zeaxanthin and the flavonoids resveratrol, quercetins, hesperidins, and other compounds such as sulphoraphane, indoles and allium compounds.
Notable Nutrients: vitamins A and C, folate, fiber, lutein, zeaxanthin, indoles, isothiocyanate, sulphoraphane.
It is rich in vegetable phytochemicals, such as glucosinolates, sulphoraphane, lycopene, lutein and chlorogenic acid.
Broccoli, along with other cruciferous vegetables such as cabbage and Brussels sprouts, is known to contain a powerful anti-cancer chemical called sulphoraphane.