sulphones


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sulphones

Drugs used to treat malaria, Hansen's disease and dermatitis herpetiformis. An example is dapsone.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
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Earlier it was assumed that under strict neutral conditions and at constant temperature the major reaction would be the condensation reaction of dichlorotriazinyl dyes with aminophenyl-P-sulphatoethyl sulphone not the hydrolysis of dichlorotriazinyl dyes or of vinyl sulphone group with water (Lewis and Loan, 2007; Weber and Vicki, 1993).
Samples of para and meta aminophenyl-Psulphatoethyl sulphone were generously provided by BASF.
Dyeing results appeared to indicate partial conversions of dichlorotriazine to a monochlorotriazine-vinyl sulphone mixed reactive system.
Meta isomer of aminophenyl-[beta]-sulphatoethyl sulphone appeared to be more effective than the para isomer.
leprae strains as a by-product of the low doses of sulphones employed in that locale.
(3) Thus for lepromatous leprosy lifelong sulphone therapy was generally recommended.
(5) The largest survey for secondary dapsone resistant relapse occurred in one of the largest leprosaria in the world, Sungi Buloh, Malaysia, (6) where 100 patients treated with sulphone monotherapy relapsed clinically (2-5% of MB patients) with strains of M.
Evidence that bacterial persistence might be a problem in the treatment of lepromatous leprosy, also, came from a study of the Karimui of Papua New Guinea in which five of 28 lepromatous patients were found to have solid-staining bacilli (indicative of live bacilli) in their skin smears despite regular treatment with acedapsone for 3-5 years and expected blood sulphone levels.
The aforementioned studies present evidence that following sulphone monotherapy persisters have the propensity to result in relapse disease.
Several studies have been carried out on epoxy blends containing thermoplastics such as poly (ether imide)s (PEIs) [5, 6] polycarbonate [7-9], poly(2,6-dimethyl-1,4-phenylene ether or oxide) (PPE or PPO) [10], and poly(ether sulphone) (PES) [11].
In particular when 3,3'DDS (3,3' diamino diphenyl sulphone) was used as curing agent the blends were homogenous without phase separation and the toughness decreased compared to the systems showing phase separation.
Name Structure Supplier Diglycidyl ether of Bisphenol A Shell (DGEBA) Epon828 3.3' Diamino Diphenyl Sulphone DDS Aldrich PES:PEES Copolymer Laboratory Made PPO General Electric FIG.