Samples of para and meta aminophenyl-Psulphatoethyl sulphone were generously provided by BASF.
Dyeing results appeared to indicate partial conversions of dichlorotriazine to a monochlorotriazine-vinyl sulphone mixed reactive system.
Meta isomer of aminophenyl-[beta]-sulphatoethyl sulphone appeared to be more effective than the para isomer.
leprae strains as a by-product of the low doses of sulphones employed in that locale.
3) Thus for lepromatous leprosy lifelong sulphone therapy was generally recommended.
5) The largest survey for secondary dapsone resistant relapse occurred in one of the largest leprosaria in the world, Sungi Buloh, Malaysia, (6) where 100 patients treated with sulphone monotherapy relapsed clinically (2-5% of MB patients) with strains of M.
Evidence that bacterial persistence might be a problem in the treatment of lepromatous leprosy, also, came from a study of the Karimui of Papua New Guinea in which five of 28 lepromatous patients were found to have solid-staining bacilli (indicative of live bacilli) in their skin smears despite regular treatment with acedapsone for 3-5 years and expected blood sulphone levels.
The aforementioned studies present evidence that following sulphone monotherapy persisters have the propensity to result in relapse disease.
Owing to concerns with sulphone resistance and the success of multidrug therapy in tuberculosis, rifampicin's inclusion in a multidrug regimen was considered required in the future treatment of leprosy.
59) A second lesson is that on both sulphone monotherapy and MDT, only skin smear-positive cases tended to relapse if therapy was discontinued and in the sulphone monotherapy era only leprosy patients with high bacterial burdens were predisposed to dapsone-resistant relapse.