He was diagnosed with axial SpA at another center 1 year before and treated with indomethacin 50 mg daily and sulphasalazine
2000 mg daily.
SD: Sprague Dawley SPF: Specific pathogen-free SAZ: Sulphasalazine
UC: Ulcerative colitis.
and male infertility: reversibility and possible mechanism.
The first-line treatment includes disease-modifying anti-rheumatic drugs (methotrexate, sulphasalazine
, leflunomide) in combination with corticosteroids, used in different dosages and routes (oral, intravenous, intraarticular).
A recent study which compared the efficacy of triple therapy (hydroxychloroquine, sulphasalazine
, and methotrexate) with hydroxychloroquine alone showed a significant improvement in disease activity and disability in the triple therapy group at 24 weeks .
(but interestingly not aminosalicylic acid)  can induce mitochondria activated apoptosis.
It is used in combination with other traditional DMARDs like methotrexate and sulphasalazine
and has proved to be effective in about 2/3rd patients.
Patient was diagnosed as AS and prescribed sulphasalazine
2 g/day, colchicine 1.5 mg/day, hydroxychloroquine 400 mg/day, diclofenac potassium 150 mg/day, and lubricant eye drops.
As for the medication, 37 (72.5%) of the patients used sulphasalazine
, 4 (7.8%) used methotrexate, 48 (94.1%) used NSAIDs and 4 (7.8%) used anti-TNF alpha drugs.
To evaluate the safety and efficacy of sulphasalazine
in treatment of severe alopecia areata.
Treatment of MRS is complex and various treatment modes have been described in literature: corticosteroids (systemic, intralesional), anabolics, antibiotics (metronidazole, tetracyclines, macrolides), clofazimine, dapsone, sulphasalazine
, azathioprine, hydroxychloroquine, methotrexate, infliximab, as well as surgical intervention (cheiloplasty), but very rarely [4, 15-17].
Exposure to medications and * Hormone/steroid therapy therapies which might have an adverse impact on * Antibiotics (sulphasalazine
) spermatogenesis * Alpha-blockers * 5-alpha-reductase inhibitors * Chemotherapeutic agents * Radiation * Finasteride (9) * Narcotics 6.