sulindac


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sulindac

 [sul´in-dak]
a nonsteroidal antiinflammatory drug, used in the treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, bursitis or tendinitis of the shoulder, and acute attacks of gout or calcium pyrophosphate deposition disease.

sulindac

/sul·in·dac/ (sul-in´dak)
1. a nonsteroidal antiinflammatory drug, analgesic, and antipyretic, used in treatment of rheumatic disorders.
2. a nonsteroidal antiinflammatory drug used in the treatment of various rheumatic and nonrheumatic inflammatory disorders.

sulindac

(sə-lĭn′dăk)
n.
A nonsteroidal anti-inflammatory drug used especially in the treatment of arthritis, tendinitis, and bursitis.

sulindac

[sulin′dek]
a nonsteroidal antiinflammatory agent.
indications It is prescribed in the treatment of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
contraindications Pregnancy (3rd trimester), lactation, or known hypersensitivity to this drug, aspirin, or nonsteroidal antiinflammatory drugs prohibits its use. It is used with caution in patients who have upper GI tract disease or impaired renal function.
adverse effects Among the more serious adverse reactions are GI upset, peptic ulcer, dizziness, tinnitus, and skin rash.

sulindac

Clinoril® An NSAID that binds to plasma proteins. See NSAIDs.

sulindac

A non-steroidal anti-inflammatory drug (NSAID). A brand name is Clinoril.

sulindac

non-steroidal anti-inflammatory drug used to control pain and inflammation in rheumatoid disease and other musculoskeletal disorders, including acute gout

sulindac (səlin´dak),

n brand name: Clinoril;
drug class: nonsteroidal antiinflammatory;
action: inhibits prostaglandin synthesis by interfering with cyclooxygenase, an enzyme needed for biosynthesis; possesses analgesic, antiinflammatory, and antipyretic properties;
uses: osteoarthritis, rheumatoid, acute gouty arthrits, tendinitis, bursitis, ankylosing spondylitis.
References in periodicals archive ?
The incidence of tumors was suppressed in the mice consuming the grape compounds alone by 50 percent, similar to the rate in the group consuming the diet with sulindac.
Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells.
Mutual, however, continues to argue that federal law preempts this type of claim, because the FDA had already approved sulindac and federal law requires a generic drug to have the same design as the brand-name medication.
Sulindac was shown in early-phase clinical studies to be efficacious in reducing the colorectal polyp burden (15,38,39).
A simple and sensitive liquid chroma- tographic method with electrochemical detection is described for the quantitative determination of the nonsteroidal anti-inflammatory drugs diflunisal, indomethacin, naproxen, piroxicam and sulindac in human plasma.
WHEN KAREN BARTLETT SUFFERED severe burns and near-blindness after taking the generic anti-inflammatory drug sulindac, she sued the maker, Mutual Pharmaceutical Co.
Success rates of between 37-57% have been reported with indomethacin and sulindac (3,8).
Synergistic effects of (-)-epigallocatechin gallate with (-)- epicatechin, sulindac.
Salicylates, sulindac, and sulfasalazine inhibit NF-[kappa]B activation by blocking IKK activity.
In some instances, COX-2 inhibitors such as celecoxib and the less commonly used NSAID sulindac, have been associated with a cholestatic injury.
16) Other possible treatment options include analgesia or non-steroidal anti-inflammatory drugs like diclofenac, etodolac or sulindac.