sulfotransferase


Also found in: Wikipedia.

sul·fo·trans·fer·ase

(sŭl'fō-trans'fĕr-ās),
Generic term for enzymes in EC sub-subclass 2.8.2 catalyzing the transfer of a sulfate group from 3'-phosphoadenylyl sulfate (active sulfate) to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.
Synonym(s): sulfikinase, sulfokinase

sul·fo·trans·fer·ase

(sŭl'fō-trans'fĕr-ās)
Generic term for enzymes in EC sub-subclass 2.8.2 catalyzing the transfer of a sulfate group from 3'-phosphoadenylyl sulfate (active sulfate) to the hydroxyl group of an acceptor.
Synonym(s): sulphotransferase.
References in periodicals archive ?
[USPRwire, Sun Aug 18 2019] Global CHST15 Antibody Market Insights, Forecast to 2025 CHST15 or Carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15, is an enzyme with an amino acid length of 561 and a mass of 64.9 kDa in humans.
Paraben esters act as estrogen agonists, androgen antagonists, inhibitors of sulfotransferase enzymes, and have genotoxic activity.
Involvement of p38 MAPK and Nrf2 in phenolic acid-induced P-form phenol sulfotransferase expression in human hepatoma HepG2 cells.
Nonstandard abbreviations: StAR, steroidogenic acute regulatory protein; CYP11A1, P450 side-chain cleavage enzyme; CYP11B1, 11[beta] hydroxylase; CYP11B2, aldosterone synthase; CYP17A1, 17 [alpha]-hydroxylase/ 17,20-lyase; CYP21A2,21-hydroxylase; HSD3B2, 3[beta]-hydroxysteroid dehydrogenase type 2; HSD11B1, 11[beta]-hydroxysteroid dehydrogenase type 1; HSD11B2, 11[beta]-hydroxysteroid dehydrogenase type 2; HSD17B, 17 [beta]-hydroxysteroid dehydrogenase; SRD5A2, 5[alpha]-reductase type 2; CYP19A1, P450 Aromatase; SULT2A1, sulfotransferase 2A1.
One was for Chiu I-an's analysis of "the role of carbohydrate sulfotransferase 11 on epithelial-to-mesenchymal transition in lung cancer" in the biomedical and health sciences category.
(1) Mutation in carbohydrate (N-acetylglucosamine6-O) sulfotransferase 6 (CHST6) gene is usually responsible for MCD.
The initial clue that led to the discovery of the RGF peptide family came from the identification of Arabidopsis tyrosylprotein sulfotransferase (TPST) (described in section 4.1, (11)), a posttranslational modification enzyme required for tyrosine sulfation.
Feng et al., "Triclosan causes spontaneous abortion accompanied by decline of estrogen sulfotransferase activity in humans and mice," Scientific Reports, vol.
The sulphation balance and pattern of CS on specific carbon residues are tightly regulated during development, injury, and disease, with the temporal and spatial expression of different chondroitin sulfotransferase isoforms [51].
However, its poor aqueous solubility, easy degradation at neutral or alkaline pH, high photosensitivity, and rapid metabolic turnover in the liver and intestine (mainly glucuronidation and sulfotransferase 1A1/1A3-mediated sulfation) resulted in weak bioavailability [24], which eventually limit its application in neuronal dysfunction treatment.
Melatonin regulates both the transcriptional levels of steroid sulfatase (STS) and 17[beta]-hydroxysteroid dehydrogenase type 1 (17[beta]-HSD1), enzymes necessary to convert inactive estrogen precursors into physiologically active estradiol; estrogen sulfotransferase (EST), the enzyme that inactivates estrogens through their conversion to inactive estrogen sulfates; and aromatase, the enzyme responsible for the aromatization of androgens into estrogens (Figure 1).
In the study, mRNA expression levels of ASBT, breast cancer-related protein (BCRP), sulfotransferase family 2A member 1 (SULT2A1), and fibroblast growth factor 19 (FGF-19) were significantly lower in inflamed regions in patients with active Crohn's ileitis than in controls.

Full browser ?