Parabens inhibit human skin estrogen sulfotransferase
activity: possible link to paraben estrogenic effects.
We observed that cytosolic PAPSS2 supported DHEA sulfation by cytoplasmic sulfotransferase
SULT2A1 to a larger extent than cytosolic PAPSS1.
During pregnancy, this enzyme oestrogen sulfotransferase
, helps metabolise oestrogen and facilitates its movement through placenta into the developing foetus.
EtG and EtS, which are generated through hepatic UDP-glucuronosyltransferase and sulfotransferase
- mediated metabolism, are highly specific biomarkers for systemic alcohol exposure.
The SANN and MEME analyses were done utilizing five co-expressed pigment cell genes: flavin-monoxidase 1, 2, 3, sulfotransferase
, and pks.
Phenotypic features of carbohydrate sulfotransferase
3 (CHST3) deficiency in 24 patients: congenital dislocations and vertebral changes as principal diagnostic features.
These include interference with enterohepatic circulation of thyroxine (17), competition with thyroid hormones for thyroid sulfotransferase
enzymes (18), inhibition of thyroid peroxidase (19) and interference with thyroid hormone synthesis by inhibition of iodide uptake and organification (8).
It could also indicate a deficiency in phenol sulfotransferase
, which can cause physical and behavioural problems.
In fact, many of them are toxins, or may disrupt normal physiologic function, as do azo dyes, which inhibit phenol sulfotransferase
P, required to break down the gut toxin p-cresol.
Reversible Covalent Inhibition of a Phenol Sulfotransferase
by Coenzyme A.
Dehydroepiandrosterone (DHEA) sulfotransferase
gene expression in human hepatocellular carcinoma: an age-dependent prognostic factor.
Among the topics are the nomenclature and molecular biology of the human sulfotransferase
family, the pharmocogenetics and pharmacogenomics of sulfate conjugation, molecular cloning of the human cytosolic sulfotransferases
in the human fetus and neonate, estrogen sulfotransferase
in breast cancer, species differences in cytosolic sulfotransferases
, and the activation and inactivation of carcinogens and mutagens by human sulfotransferases